Effects of dietary education, followed by a tailored fructose-restricted diet in adults with fructose malabsorption
Effects of dietary education, followed by a tailored fructose-restricted diet in adults with fructose malabsorption
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DOI：
10.1097/meg.0000000000000374
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发表时间：
2015-07-01
影响因子：
2.1
通讯作者：
Portincasa, Piero
中科院分区：
文献类型：
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作者：
Bonfrate, Leonilde;Krawczyk, Marcin;Portincasa, Piero
目的果糖在小肠中被过剩的转运体吸收。如果这一过程不充分，可能会出现因果糖不耐受而引起的腹部症状。在果糖呼气试验(50g)异常后，107例患者(也患有乳糖不耐受)进入三个研究阶段：0-32周(无糖饮食)、32-36周(果糖量递增至诱发症状的数量、触发剂量)和36-48周(根据触发剂量量身定制限制果糖饮食)。15名患者接受了额外的果糖呼气试验(35，25g)，以比较三种不同剂量。结果基线时，最常见的症状是腹胀和腹痛，更严重的是合并果糖和乳糖不耐受。在自由饮食期间，患者报告停止(48%)或减少(52%)含有果糖的食物，症状显著改善(腹痛从79.71.3到19.3+/-1.8 mm；腹胀从83.1+/-1.3到19.4+/-1.8 mm；每天疏散次数从3.9+/-0.16到1.1+/-0.04；Bristol评分从5.1+/-0.14到3.8+/-0.1，P
ObjectiveFructose is absorbed by GLUT transporters in the small intestine. If this process is inadequate, abdominal symptoms because of fructose intolerance may arise. The effect of a tailored fructose-restricted diet on gastrointestinal complaints was assessed in patients with fructose intolerance.Materials and methodsFollowing an abnormal fructose breath test (50g), 107 patients (64 also with lactose intolerance) entered three study periods: weeks 0-32 (free diet), weeks 32-36 (progressive increasing amount of fructose up to quantity inducing symptoms, trigger dose'), and weeks 36-48 (tailored fructose-restricted diet according to the trigger dose'). A subgroup of 15 patients underwent additional fructose breath tests (35, 25g) to compare three different doses.ResultsAt baseline, the most frequent symptoms were bloating and abdominal pain, and were more severe with combined fructose and lactose intolerance. During the free diet, patients reported eliminating (48%) or reducing (52%) fructose-containing foods, with a significant improvement in symptoms (abdominal pain from 79.71.3 to 19.3 +/- 1.8mm; bloating from 83.1 +/- 1.3 to 19.4 +/- 1.8mm; number of evacuations/day from 3.9 +/- 0.16 to 1.1 +/- 0.04; Bristol score from 5.1 +/- 0.14 to 3.8 +/- 0.1, P