Induction of HIV-1 specific mucosal immune responses by DNA vaccination
Induction of HIV-1 specific mucosal immune responses by DNA vaccination
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DOI：
10.1046/j.1365-3083.1997.d01-146.x
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发表时间：
1997-10-01
影响因子：
3.7
通讯作者：
Wahren, B
中科院分区：
文献类型：
--
作者：
Asakura, Y;Hinkula, J;Wahren, B
DNA疫苗已被证明可以诱导对包括HIV-1在内的几种不同病原体的免疫。作者在此证明，通过鼻腔途径接种DNA疫苗足以在远端粘膜部位和全身诱导免疫反应。由于HIV-1的传播主要发生在粘膜表面，鼻腔途径为DNA免疫提供了另一种应用手段。
DNA vaccination has been shown to induce immunity against several different pathogens including HIV-1. The authors demonstrate here that administration of DNA vaccines via the intranasal route is sufficient to induce immune responses both at distal mucosal sites and systemically. Since transmission of HIV-1 occurs largely across mucosal surfaces, the intranasal route provides a further means of application for DNA immunization.