Caries inhibition of simulated active caries lesions with CO2 laser irradiation and fluoride.
Caries inhibition of simulated active caries lesions with CO2 laser irradiation and fluoride.
复制标题
CO2 激光照射和氟化物对模拟活动性龋齿病变的龋齿抑制作用。
DOI：
10.1117/12.2608308
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Fried,Daniel
中科院分区：
文献类型：
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作者：
Tressel,John;Kashirtsev,Filipp;Cheung,Kevin;Simon,Jacob;Fried,Daniel
CO2激光照射可以改变牙釉质的矿物相，使其更耐酸溶解。本研究的目的是研究二氧化碳激光照射和局部氟化物是否可用于治疗初期龋齿病变以抑制进一步发展，即在对活性病变表面进行酸挑战之前，治疗活性病变表面而不是健康表面。用9.4 μ mCO_2激光照射28个牛牙釉质表面，用pH循环模型模拟龋坏，并进行局部氟化物处理。使用数字显微镜，光学相干断层扫描（OCT），和SWIR反射表面脱水率测量在1950 nm暴露后，进一步的酸挑战的表面形态，耐酸性和渗透性的变化进行了测量。与未处理的病变窗相比，在每个样本上，用CO2激光照射后应用酸化磷酸盐氟化物凝胶处理的病变窗的进一步病变进展显著减少（P < 0.05）。单纯激光照射治疗无效。损伤抑制的程度不像以前观察到的激光照射的声音釉质表面暴露于酸的挑战。
It has been well established that CO2laser irradiation can be used to transform the mineral phase of dental enamel to make it more resistant to acid dissolution. The purpose of this study was to investigate if carbon dioxide laser irradiation and topical fluoride can be used to treat incipient caries lesions to inhibit further progression, i.e. treat active lesion surfaces as opposed to sound surfaces prior to subjecting them to an acid challenge. Simulated active caries lesions were produced on twenty eight bovine enamel samples using a pH cycling model and those surfaces were irradiated by a 9.4 μm CO2laser and treated with topical fluoride. Changes in the surface morphology, acid resistance, and permeability were measured using digital microscopy, optical coherence tomography (OCT), and SWIR reflectance surface dehydration rate measurements at 1950 nm after exposure to a further acid challenge. There was a significant reduction (P < 0.05) of further lesion progression for lesion windows treated with CO2laser irradiation followed by the application of an acidulated phosphate fluoride gel compared to the untreated lesion windows on each sample. Treatment by laser irradiation alone was not effective. The degree of lesion inhibition was not as high as has been previously observed for laser irradiated sound enamel surfaces exposed to an acid challenge.