CELL SURFACE AND EXTRACELLULAR MATRIX GLYCOPROTEIN FIBRONECTIN: EXPRESSION IN EMBRYOGENESIS AND IN TERATOCARCINOMA DIFFERENTIATION *
CELL SURFACE AND EXTRACELLULAR MATRIX GLYCOPROTEIN FIBRONECTIN: EXPRESSION IN EMBRYOGENESIS AND IN TERATOCARCINOMA DIFFERENTIATION *
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细胞表面和细胞外基质糖蛋白纤连蛋白：在胚胎发生和畸胎瘤分化中的表达 *
DOI：
10.1111/j.1749-6632.1978.tb16798.x
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发表时间：
1978
影响因子：
5.2
通讯作者：
C. Graham
中科院分区：
文献类型：
--
作者：
J. Wartiovaara;I. Leivo;I. Virtanen;A. Vaheri;C. Graham
细胞表面糖蛋白纤连蛋白特征性地存在于各种脊椎动物物种的成纤维细胞和血清中。类似的蛋白质有不同的名称（SF抗原、LETS蛋白、CIG、CSP、Z蛋白）。尽管关于它们的化学和免疫学相似性的确切信息仍然缺乏，但这些蛋白质似乎在很大程度上是相似的。在成人和胚胎组织中，纤连蛋白主要局限于基底层和细胞外基质物质。我们的目的是描述在小鼠个体发育的不同阶段和小鼠畸胎瘤分化成胚状体的过程中纤维连接蛋白的形成，这一过程在一定程度上模拟了早期发育。目前，纤连蛋白被认为在形态发生现象中细胞的定位和维持有序的组织结构中发挥作用。
The cell surface glycoprotein fibronectin is characteristically present in fibroblasts and sera 01' various vertebrate species. Similar proteins have been given various names (SF antigen, LETS protein, CIG, CSP, Z protein). Although definite information on their chemical andimmunologic similarities is still lacking, the proteins appear to be largely alike.' In adult17 and embryonic tissue,2 fibronectin is largely confined to basal laminae and extracellular matrix material. It is o u r purpose here to describe the formation of fibronectin as seen by indirect immunofluorescence techniques in different stages of ontogenesis in the mouse and during mouse teratocarcinoma differentiation into structures called embryoid a process that to a certain degree mimics early development.' At present, fibronectin is believed to play a role in the positioning of cells in morphogenctic phenomena and in the maintenance of orderly tissue organization.