Chemical Synthesis Accelerated by Paper Spray: The Haloform Reaction
Chemical Synthesis Accelerated by Paper Spray: The Haloform Reaction
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DOI：
10.1021/acs.jchemed.5b00263
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发表时间：
2016-02-01
影响因子：
3
通讯作者：
Cooks, Graham
中科院分区：
文献类型：
--
作者：
Bain, Ryan M.;Pulliam, Christopher J.;Cooks, Graham
在这个实验室里，学生们以两种方式进行合成反应：（i）通过传统的体相反应和（ii）在反应纸的过程中。喷雾电离质谱法（MS）既可用作分析方法，也可用作加速有机合成的手段。这个实验室练习的主要重点是，可以操作相同的电离源来进行化学分析或加速合成。更具体地说，学生探索在纸喷雾电离的两种模式之一的操作反应进程的影响。这些模式与液滴尺寸有关，液滴尺寸随着溶剂从纸中耗尽而变化。这两种模式的在线质谱数据使学生能够看到喷雾条件的微小变化对反应混合物的MS的影响，从而允许从传统分析过渡到加速化学合成，只需让纸张部分干燥。化学分析和加速合成可以在一个简单的2分钟纸喷雾实验中用卤仿氧化依次进行。
In this laboratory, students perform a synthetic reaction in two ways: (i) by traditional bulk-phase reaction and (ii) in the course of reactive paper. spray ionization. Mass spectrometry (MS) is used both as an analytical method and a means of accelerating organic syntheses. The main focus of this laboratory exercise is that the same ionization source can be operated to perform chemical analysis or to accelerate synthesis. More specifically, students explore the effect on reaction progress of operating in one of two modes of paper spray ionization. The modes relate to droplet size that changes as the solvent is depleted from the paper over time. The online mass spectral data for the two modes allow students to see the differences that small changes to spray conditions can have on the MS of a reaction mixture, allowing transition from traditional analysis to accelerated chemical synthesis by simply allowing the paper to partially dry. Chemical analysis and accelerated synthesis can be performed sequentially in one simple, 2 min paper spray experiment with the haloform oxidation.