Potential risk of acute hepatotoxicity of kodo poisoning due to exposure to cyclopiazonic acid
Potential risk of acute hepatotoxicity of kodo poisoning due to exposure to cyclopiazonic acid
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DOI：
10.1016/s0378-8741(03)00146-6
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发表时间：
2003-08-01
影响因子：
5.4
通讯作者：
Janardhanan, KK
中科院分区：
文献类型：
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作者：
Antony, M;Shukla, Y;Janardhanan, KK
科多小米（Paspalum scrobiculatum L.）是北印度某些地区人民的主食。食用科多小米经常被发现会导致中毒。这些谷物经常感染北曲霉，产生大量的霉菌毒素。环吡嗪酸（CPA）。进行研究以评估单剂量和多剂量 CPA 给药后大鼠肝脏的肝毒性/肿瘤前变化。结果显示，接触 CPA 后，谷氨酸丙酮酸转氨酶 (GPT) 和谷氨酸草酰乙酸转氨酶 (GOT) 的活性显着增加，表明存在急性肝毒性。暴露于 CPA 后，还观察到 γ 谷氨酰转肽酶 (GGT) 活性显着增加，表明肝脏发生肿瘤前变化。结果表明，科多兽中毒可能会导致人类和动物出现急性肝毒性。因此，研究结果表明，食用受污染的科多小米会对健康造成严重危害，因为它会接触到与小米相关的曲霉菌产生的 CPA。 (C) 2003 Elsevier Science Ireland Ltd. 保留所有权利。
Kodo millet (Paspalum scrobiculatum L.) is a staple food of some sections of people of North India. Consumption of Kodo millet is often found to cause intoxication and poisoning. The grains are frequently infested with Aspergillus tamarii Kita, which produced substantial amount of a mycotoxin. cyclopiazonic acid (CPA). Investigations were carried out to evaluate the hepatotoxic/preneoplastic changes in rat liver following single and multiple dose administration of CPA. Results showed a marked increase in the activity of glutamate pyruvate transaminase (GPT) and glutamate oxaloacetate transaminase (GOT) following CPA exposures, suggesting acute hepatotoxicity. Significant increase was also observed in gamma glutamyl transpeptidase (GGT) activity following CPA exposures, indicating preneoplastic changes in the liver. The results reveal that Kodo poisoning might cause acute hepatotoxicity in men and animals. The findings thus suggest that the consumption of contaminated Kodo millet is a serious health hazard due to exposure to CPA produced by Aspergillus tamarii associated with the millet. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.