KnotProt 2.0: a database of proteins with knots and other entangled structures
KnotProt 2.0: a database of proteins with knots and other entangled structures
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DOI：
10.1093/nar/gky1140
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发表时间：
2019-01-08
影响因子：
14.9
通讯作者：
Sulkowska, Joanna I.
中科院分区：
文献类型：
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作者：
Dabrowski-Tumanski, Pawel;Rubach, Pawel;Sulkowska, Joanna I.
KnotProt 2.0数据库（KnotProt数据库的更新版本）收集有关形成结和其他纠缠结构的蛋白质的信息。KnotProt 2.0中的新功能包括概率性和确定性纠缠的表征，这些纠缠可以通过二硫键和离子相互作用形成，在knotoids方面对纠缠进行了精细表征，识别所谓的半胱氨酸结，分析所有或非冗余蛋白质组的可能性，以及各种技术更新。KnotProt 2.0数据库对所有缠结蛋白质进行分类，以打结指纹的形式表示它们的复杂性，并基于这些结果呈现许多生物学和几何统计数据。目前，该数据库包含超过2000个纠缠结构，并定期根据蛋白质数据库（PDB）中存储的蛋白质进行自我更新。
The KnotProt 2.0 database (the updated version of the KnotProt database) collects information about proteins which form knots and other entangled structures. New features in KnotProt 2.0 include the characterization of both probabilistic and deterministic entanglements which can be formed by disulfide bonds and interactions via ions, a refined characterization of entanglement in terms of knotoids, the identification of the so-called cysteine knots, the possibility to analyze all or a non-redundant set of proteins, and various technical updates. The KnotProt 2.0 database classifies all entangled proteins, represents their complexity in the form of a knotting fingerprint, and presents many biological and geometrical statistics based on these results. Currently the database contains >2000 entangled structures, and it regularly self-updates based on proteins deposited in the Protein Data Bank (PDB).