The effect of serotonin and serotonin receptor antagonists on motion sickness in Suncus murinus
The effect of serotonin and serotonin receptor antagonists on motion sickness in Suncus murinus
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DOI：
10.1016/s0091-3057(02)00955-3
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发表时间：
2002-11-01
影响因子：
3.6
通讯作者：
Naylor, RJ
中科院分区：
文献类型：
--
作者：
Javid, FA;Naylor, RJ
在本研究中，我们研究了 5-羟色胺 (5-HT) 和 5-HT 受体激动剂和拮抗剂对运动的影响。 Suncus murinus 的晕动病，以及 5-HT 的催吐刺激可能会改变动物对晕动病的不同催吐刺激的敏感性，5-HT（1.0、2.0、4.0 和 8.0 mg/kg ip）诱导呕吐，并且被 5-HT4 受体拮抗剂美西麦角（1.0 mg/kg ip）拮抗。氨基磺酸盐[1-[2-[(甲基磺酰基)氨基]乙基]-4-哌啶基]甲基-5-氟-2-甲氧基-1H-吲哚-3-羧酸酯(GR125487D-，1.0 mg/kg ip)和格拉司琼(0.5 mg/kg ip)，用5-HT预处理引起由随后的运动刺激引起的呕吐反应的剂量相关性减弱，这是美西麦角、格拉司琼或 GR125487D 预处理、(+)-1-(2,5-二甲氧基-4-碘苯基)-2-氨基-丙烷 (DOI: 0.5 和 1.0 mg/kg ip)、8-羟基-2(二正丙氨基)四氢萘 (8-OH-DPAT; 0.1 mg/kg ip) 未显着改变，但美西麦角、GR125487D 或格拉司琼，可减轻运动引起的呕吐，并且不受酮色林 (2.0 mg/kg，腹腔注射) 或 N-{2-[4-(2-甲氧基苯基)-1-哌嗪基]乙基}-N-(2. 吡啶基)环己烷甲酰胺三氢氯化物预处理的影响 (WAY-100635: 1.0 mg/kg ip)，分别。事实上，单独的酮舍林(0.1、0.3、1.0和2.0mg/kg ip)可减轻晕动病。这些数据表明5-HT1、2、5-HT3和5-HT4受体参与5-HT诱发的呕吐的诱导。然而，5-HT1A7 和 5-HT2 受体的激动剂作用以及 5-HT2A 受体的拮抗剂作用可以减轻鼠鼠的晕动病，(C) 2002 Elsevier Science Inc. 保留所有权利。
In the present study, we investigated the effect of 5-hydroxytrytamine (5-HT) and 5-HT receptor agonists and antagonists on motion. p sickness in Suncus murinus, and the possibility that the emetic stimulus of 5-HT can alter the sensitivity of the animals to the different emetic stimulus of motion sickness, 5-HT (1.0, 2.0, 4.0 and 8.0 mg/kg ip) induced emesis and that was antagonised by methysergide (1.0 mg/kg ip), the 5-HT4 receptor antagonist sulphamate[1-[2-[(methylsulphonyl)amino]ethyl]-4-piperidinyl]methyl-5-fluoro-2-methoxy-1H-indole-3-carboxylate (GR125487D-, 1.0 mg/kg ip) and granisetron (0.5 mg/kg ip), Pretreatment with 5-HT caused a dose-related attenuation of the emetic response induced by a subsequent motion stimulus, which was not significantly modified by methysergide, granisetron or GR125487D pretreatment, (+)-1-(2,5-Dimethoxy-4-iodophenyl)-2-amino-propane (DOI: 0.5 and 1.0 mg/kg ip), 8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT; 0.1 mg/kg ip) but not methysergide, GR125487D or granisetron, attenuated motion-induced emesis, and that was not affected by pretreatment with ketanserin (2.0 mg/kg, ip) or N-{2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl}-N-(2. pridinyl)cyclohexanecarboxamide trihydrocholoride (WAY-100635: 1.0 mg/kg ip), respectively. Indeed, ketanserin alone (0.1, 0.3, 1.0 and 2.0 mg/kg ip) attenuated motion sickness, These data indicate that 5-HT1 2, 5-HT3 and 5-HT4 receptors are involved in the induction of 5-HT-induced emesis. However, agonist action at the 5-HT1A7 and 5-HT2 receptors, and antagonist action at the 5-HT2A receptors can attenuate motion sickness in S. murinus, (C) 2002 Elsevier Science Inc. All rights reserved.