Catalytic Synthesis of Enantiopure Chiral Alcohols via Addition of Grignard Reagents to Carbonyl Compounds
Catalytic Synthesis of Enantiopure Chiral Alcohols via Addition of Grignard Reagents to Carbonyl Compounds
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DOI：
10.1021/acscatal.5b02832
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发表时间：
2016-03-01
期刊：
影响因子：
12.9
通讯作者：
Macia, Beatriz
中科院分区：
文献类型：
--
作者：
Collados, Juan F.;Sola, Ricard;Macia, Beatriz
格氏试剂对羰基化合物的不对称加成反应在过去的十年中取得了显著的进展。这种对映选择性转化现在允许使用这些具有挑战性的反应性亲核试剂，用于使用催化量的手性配体形成手性醇。本文综述了这一领域的发展。
Remarkable progress in the enantioselective addition of Grignard reagents to carbonyl compounds has been made over the past decade. This enantioselective transformation now allows the use of these challenging reactive nucleophiles for the formation of chiral alcohols using catalytic amounts of chiral ligands. This review summarizes the developments in this area.