Accumulation of DNA damage in the aged hematopoietic stem cell compartment.
Accumulation of DNA damage in the aged hematopoietic stem cell compartment.
复制标题
老化的造血干细胞室中 DNA 损伤的积累。
DOI：
10.1053/j.seminhematol.2016.11.001
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发表时间：
2017-01
影响因子：
3.6
通讯作者：
Beerman I
中科院分区：
文献类型：
--
作者：
Beerman I
衰老与多个组织系统的功能潜力丧失有关，并且人们对理解组织特异性细胞如何促成这种下降产生了极大的兴趣。DNA损伤积累与分化细胞类型的衰老广泛相关。然而，组织特异性干细胞曾经被认为是基因保护的群体，因为干细胞群体中累积的损伤具有被分化的后代遗传以及通过自我更新分裂在干细胞区室内繁殖的潜力。这篇综述将讨论DNA损伤积累的证据，在老年HSC隔室，潜在的驱动程序，并最终获得性损伤的后果。
Aging is associated with loss of functional potential of multiple tissue systems, and there has been significant interest in understanding how tissue specific cells contribute to this decline. DNA damage accumulation has been widely associated with aging in differentiated cell types. However, tissue specific stem cells were once thought to be a geno-protected population, as damage accrued in a stem cell population has the potential to be inherited by differentiated progeny as well as propagated within the stem cell compartment through self-renewal divisions. This review will discuss the evidence for DNA damage accumulation in the aged HSC compartment, potential drivers, and finally the consequences of the acquired damage.