Optical CT reconstruction of 3D dose distributions using the ferrous-benzoic-xylenol (FBX) gel dosimeter
Optical CT reconstruction of 3D dose distributions using the ferrous-benzoic-xylenol (FBX) gel dosimeter
复制标题
DOI：
10.1118/1.598356
复制
发表时间：
1998-09-01
期刊：
影响因子：
3.8
通讯作者：
Battista, JJ
中科院分区：
文献类型：
--
作者：
Kelly, RG;Jordan, KJ;Battista, JJ
近年来，磁共振成像的明胶掺杂的Sparkke解决方案已被应用于直接测量的三维（3D）辐射剂量分布。然而，3D剂量分布也可以使用光学吸收计算机断层扫描的方法更经济和有效地成像。这是通过首先制备含有辐射致变色染料的明胶基质并绘制辐射诱导的光吸收系数局部变化来实现的。铁-苯甲酸-二甲苯酚（FBX）是本研究选择的染料。由Fe 3+和二甲酚橙子形成的络合物在0和1000 cGy之间的辐射剂量范围内显示出光学衰减（cm（-1））的线性变化，并且可以使用绿色激光（λ =543.5 nm）探测该络合物的局部浓度。光学计算机断层扫描（CT）扫描仪的构造类似于第一代X射线CT扫描仪，使用He-Ne激光器，光电二极管，和旋转平移台由个人计算机控制。光学CT扫描仪本身可以将衰减系数重建到基线精度
In recent years, magnetic-resonance imaging of gelatin doped with the Fricke solution has been applied to the direct measurement of three-dimensional (3D) radiation dose distributions. However, the 3D dose distribution can also be imaged more economically and efficiently using the method of optical absorption computed tomography. This is accomplished by first preparing a gelatin matrix containing a radiochromic dye and mapping the radiation-induced local change in the optical absorption coefficient. Ferrous-Benzoic-Xylenol (FBX) was the dye of choice for this investigation. The complex formed by Fe3+ and xylenol orange exhibits a linear change in optical attenuation (cm(-1)) with radiation dose in the range between 0 and 1000 cGy, and the local concentration of this complex can be probed using a green laser light (lambda=543.5 nm). An optical computed tomography (CT) scanner was constructed analogous to a first-generation x-ray CT scanner, using a He-Ne laser, photodiodes, and rotation-translation stages controlled by a personal computer. The optical CT scanner itself can reconstruct attenuation coefficients to a baseline accuracy of