Antineuronal antibodies in systemic lupus erythematosus.
Antineuronal antibodies in systemic lupus erythematosus.
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系统性红斑狼疮中的抗神经元抗体。
DOI：
10.1002/art.1780250711
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发表时间：
1982
影响因子：
--
通讯作者：
WoodsJr,VL
中科院分区：
文献类型：
--
作者：
Bluestein,HG;WoodsJr,VL
最早的自体免疫疾病的概念来自于对某些贫血病人产生溶血性抗体与自身红细胞反应的认识。因此，随后的自身免疫研究强调了细胞膜抗原抗体在疾病发病机制中的作用。几十年后，对以累及几个不同器官系统为特征的疾病的分析证明了循环抗原抗体复合物的重要性。免疫CM复合物的炎症特性已被认识，免疫复合物诱导的血管炎模型被证明与系统性红斑狼疮（SLE）等疾病的多系统受累特征有关。自身免疫性疾病的概念扩大了，事实上，细胞和器官特异性自身抗体的作用被淡化了，在过去的十年中，淋巴细胞反应性抗体与SLE临床特征相关性的广泛分析（1）导致了对细胞膜抗原自身抗体在该疾病发病机制中作用的重新关注。抗淋巴细胞活性，由于其改变免疫调节的潜力，可以放大对其他自身抗原的免疫应答的异质性和强度。几项研究已经证明了抗淋巴细胞抗体水平与SLE总体疾病活动性之间的相关性（2-5）。此外，循环淋巴细胞毒性抗体的量与中枢神经系统（CNS）和血液学表现特异性相关（2-6）。
The earliest concepts of autoimmune disease were derived fran the recognition that certain patients with anemia produce hemolytic antibodies that react with their own red cells. As a result, subsequent studies of autoimmunity emphasized the role of antibodies to cell membrane antigens in the pathogenesis of disease. Decades later, analysis of diseases characterized by involvement of several different organ systems demnstrated the importance of circulating antigen-antibody complexes. The phlogisticpropertieso f immune CM-plexes were recognized, and models of immune complex induced vasculitis were shown to be relevant to the multisystemic involvement characteristic of diseases like systemic lupus erythematosus (SLE). The concepts of autoimnune disease expanded and, in fact, the role of cell and organ specific autoantibodies was deemphasized.During the past decade, the extensive analysis of the relevance of lymphocyte reactive antibodies to the clinical features of SLE (1) has lead to a renewed interest in the role of autoantibodies to cell membrane antigens in the pathogenesis of that disease. Antilymphocyte activity, by virtue of its potential for altering imne regulation, may amplify the heterogeneity, as well as the magnitude, of immune responses to other self antigens. Several studies have now documented a correlation between antilymphocyte antibody levels and overall disease activity in SLE (2-5). In addition, the amount of circulating lymphocytotoxic antibody has been associated specifically with central nervous system (CNS) and hematologic manifestations (2-6).