Endocrine Aspects of Post-traumatic Stress Disorder and Implications for Diagnosis and Treatment
Endocrine Aspects of Post-traumatic Stress Disorder and Implications for Diagnosis and Treatment
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DOI：
10.1016/j.ecl.2013.05.004
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发表时间：
2013-09-01
影响因子：
4.5
通讯作者：
Yehuda, Rachel
中科院分区：
文献类型：
--
作者：
Daskalakis, Nikolaos P.;Lehrner, Amy;Yehuda, Rachel
创伤后应激障碍（PTSD）是一种严重的多系统疾病，伴有多种医学合并症。本文回顾了目前的文献PTSD的内分泌方面，特别是下丘脑-垂体-肾上腺轴的变化表明低皮质醇和糖皮质激素敏感性增加，并提出了这些改变增加风险或反映病理生理机制。讨论包括新的治疗创新和未来研究的方向。
Post-traumatic stress disorder (PTSD) is a serious, multisystem disorder with multiple medical comorbidities. This article reviews the current literature on the endocrine aspects of PTSD, specifically hypothalamic-pituitary-adrenal axis alterations indicative of low cortisol and increased glucocorticoid sensitivity, and the proposed mechanisms whereby these alterations increase risk or reflect pathophysiology. Discussion includes novel treatment innovations and directions for future research.