GROWTH-HORMONE INCREASES RATE OF PUBERTAL MATURATION
GROWTH-HORMONE INCREASES RATE OF PUBERTAL MATURATION
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DOI：
10.1530/acta.0.1220414
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发表时间：
1990-03-01
期刊：
影响因子：
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通讯作者：
BROOK, CGD
中科院分区：
文献类型：
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作者：
DARENDELILER, F;HINDMARSH, PC;BROOK, CGD
我们对134例GH治疗的单纯GH不足儿童的青春期参数进行了回顾性分析，并将其与坦纳的标准和最近在英国进行的生长发育纵向研究进行了比较。发现青春期开始的年龄（男孩13.0岁，女孩12.1岁）显著延迟（Mann-Whitney p < 0.001），但青春期持续时间（男女均为1.5年）缩短（Kolgomarov-Smirnov p < 0.01）。 排除这一因素，青春期开始时的骨骼成熟度并不提前。GH给药剂量与青春期参数之间无相关性。结果表明，生长激素加速青春期的进程。
We have performed a retrospective analysis of the pubertal parameters of 134 children with isolated GH insufficiency on GH treatment and compared them to the standards of Tanner and to a recent longitudinal study of growth and development in the United Kingdom. The age at onset of puberty (13.0 years in boys, 12.1 years in girls) was found to be significantly delayed (Mann-Whitney p < 0.001), but duration of puberty (1.5 years in both sexes) was shortened (Kolgomarov-Smirnov p < 0.01). Skeletal maturity at the onset of puberty was not advanced excluding this as a contributory factor. There was no association between dose of GH administered and the pubertal parameters. The results suggest that GH accelerates the pubertal process.