An overview of mechanisms of redox signaling.
An overview of mechanisms of redox signaling.
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DOI：
10.1016/j.yjmcc.2014.01.018
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发表时间：
2014-08
影响因子：
5
通讯作者：
Maiorino, Matilde
中科院分区：
文献类型：
--
作者：
Forman, Henry Jay;Ursini, Fulvio;Maiorino, Matilde
关键词：
氧化还原信号传导的主要特征是它涉及传感器信号传导蛋白和第二信使之间的氧化还原反应或共价加合物形成。非氧化还原信号传导可能涉及第二信使的改变，如G蛋白水解GTP，法尼基化中信号蛋白的修饰，或激动剂或第二信使的简单非共价结合。氧化还原信号的化学在这里进行审查。具体来说，我们已经描述了在所谓的活性氧物质中，只有氢过氧化物明确适合第二信使的作用。反应动力学和细胞位置的考虑强烈表明，对于氢过氧化物，特定的蛋白质半胱氨酸是目标，并且氧化还原信号传导的要求是这些半胱氨酸处于微环境中，其中半胱氨酸被离子化为硫醇盐，并且可以提供质子以形成离去基团。这里描述的化学与通常被认为是对抗氧化应激的主要防御的半胱氨酸和硒代半胱氨酸过氧化物酶中发生的化学相同。但是，这些相同的酶也可以作为信号的传感器和换能器。还定义了允许过氧亚硝酸盐和超氧化物的特异性信号传导的条件。其他亲电体的信号传导，包括脂质过氧化产物、由多酚和其他代谢物形成的醌，也涉及与特定蛋白质硫醇盐的反应。同样，动力学和位置是提供生理信号传导所需的特异性的主要决定因素，尽管不太可能涉及酶催化。
A principal characteristic of redox signaling is that it involves an oxidation-reduction reaction or covalent adduct formation between the sensor signaling protein and second messenger. Non-redox signaling may involve alteration of the second messenger as in hydrolysis of GTP by G proteins, modification of the signaling protein as in farnesylation, or simple non-covalent binding of an agonist or second messenger. The chemistry of redox signaling is reviewed here. Specifically we have described how among the so-called reactive oxygen species, only hydroperoxides clearly fit the role of a second messenger. Consideration of reaction kinetics and cellular location strongly suggests that for hydroperoxides, particular protein cysteines are the targets and that the requirements for redox signaling is that these cysteines are in microenvironments in which the cysteine is ionized to the thiolate, and a proton can be donated to form a leaving group. The chemistry described here is the same as occurs in the cysteine and selenocysteine peroxidases that are generally considered the primary defense against oxidative stress. But, these same enzymes can also act as the sensors and transducer for signaling. Conditions that would allow specific signaling by peroxynitrite and superoxide are also defined. Signaling by other electrophiles, which includes lipid peroxidation products, quinones formed from polyphenols and other metabolites also involves reaction with specific protein thiolates. Again, kinetics and location are the primary determinants that provide specificity required for physiological signaling although enzymatic catalysis is not likely involved.
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影响因子：
64.8
作者：
Chen, Chun-An;Wang, Tse-Yao;Varadharaj, Saradhadevi;Reyes, Levy A.;Hemann, Craig;Talukder, M. A. Hassan;Chen, Yeong-Renn;Druhan, Lawrence J.;Zweier, Jay L.
通讯作者：
Zweier, Jay L.
影响因子：
4.8
作者：
Gow, AJ;Buerk, DG;Ischiropoulos, H
通讯作者：
Ischiropoulos, H
影响因子：
3.9
作者：
FORMAN, HJ;FRIDOVICH, I
通讯作者：
FRIDOVICH, I
影响因子：
7.3
作者：
Doulias PT;Tenopoulou M;Greene JL;Raju K;Ischiropoulos H
通讯作者：
Ischiropoulos H
DOI：
10.1016/j.bbagen.2013.02.017
发表时间：
2013-06-01
影响因子：
3
作者：
Bosello-Travain, Valentina;Conrad, Marcus;Maiorino, Matilde
通讯作者：
Maiorino, Matilde