Ionic liquid droplet as e-microreactor
Ionic liquid droplet as e-microreactor
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DOI：
10.1021/ac060481q
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发表时间：
2006-07-15
影响因子：
7.4
通讯作者：
Vaultier, Michel
中科院分区：
文献类型：
--
作者：
Dubois, Philippe;Marchand, Gilles;Vaultier, Michel
据报道，一种强大的方法结合了基于液滴的开放式数字微流控芯片实验室，使用特定任务的离子液体作为可溶性载体来执行溶液合成，成为化学应用的一种新工具。离子液体的挥发性可以忽略不计，这使得它们可以在空气中用作芯片表面的稳定液滴反应器。这一概念在不同的离子液体和多组分反应中得到验证。事实上，我们证明了不同的离子液体可以通过电润湿介质(EWOD)来移动，并将它们的置换与水溶液进行了比较。此外，我们还表明，在“开放”系统中混合离子液体液滴，每个液滴都含有不同的试剂，是进行支撑有机合成的一种有效方式。并将其应用于Grieco的四氢喹啉类化合物的合成。对最终产物进行了离线和在线分析，并与常规反应瓶中的结果进行了比较。这项技术为轻松合成微量化合物开辟了道路，而无需使用复杂、昂贵和笨重的机器人，并允许在便携式设备中实现嵌入化学的过程的完全自动化。它具有几个优点，包括使用简单、灵活性和可扩展性，并且似乎是对通常基于微通道中连续流动的传统微流控芯片上实验室设备的补充。
A powerful approach combining a droplet-based, open digital microfluidic lab-on-a-chip using task-specific ionic liquids as soluble supports to perform solution-phase synthesis is reported as a new tool for chemical applications. The negligible volatility of ionic liquids enables their use as stable droplet reactors on a chip surface under air. The concept was validated with different ionic liquids and with a multicomponent reaction. Indeed, we showed that different ionic liquids can be moved by electrowetting on dielectric (EWOD), and their displacement was compared with aqueous solutions. Furthermore, we showed that mixing ionic liquids droplets, each containing a different reagent, in "open" systems is an efficient way of carrying supported organic synthesis. This was applied to Grieco's tetrahydroquinolines synthesis with different reagents. Analysis of the final product was performed off-line and on-line, and the results were compared with those obtained in a conventional reaction flask. This technology opens the way to easy synthesis of minute amounts of compounds ad libitum without the use of complex, expensive, and bulky robots and allows complete automation of the process for embedded chemistry in a portable device. It offers several advantages, including simplicity of use, flexibility, and scalability, and appears to be complementary to conventional microfluidic lab-on-a-chip devices usually based on continuous-flow in microchannels.