Dopaminergic effects on electrophysiological and functional MRI measures of human cortical stimulus-response power laws
Dopaminergic effects on electrophysiological and functional MRI measures of human cortical stimulus-response power laws
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DOI：
10.1016/j.neuroimage.2003.09.067
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发表时间：
2004-02-01
期刊：
影响因子：
5.7
通讯作者：
Bullmore, ET
中科院分区：
文献类型：
--
作者：
Arthurs, OJ;Stephenson, CME;Bullmore, ET
功率定律已被广泛用于制定刺激的客观强度和感觉强度之间的关系。我们研究了多巴胺能药物治疗（硫酸盐）对通过体感诱发的电位（SEP）和功能磁共振成像（FMRI）在电生理上测量的体感刺激强度与皮质反应之间的关系。刺激的强度通过简单的功率定律与皮质反应的电生理和功能磁共振成像量度有关，这两个功率定律指数都重叠置信区间。硫磺没有调节功率定律指数，而是显着衰减了两个刺激 - 反应函数的“增益”。使用路径分析，我们将fMRI数据的多巴胺能作用分解为间接成分（16％），可以通过药物对SEP的影响和直接成分（84％）预测，而不是在电生理上解释。结果表明，硫磺对SEP和fMRI估计的功率定律参数具有可比的影响，但是fMRI具有较高的敏感性，可以通过分级刺激来检测药物对体感皮质募集的影响。 （c）2003 Elsevier Inc.保留所有权利。
Power laws have been widely used to formulate relationships between objective intensity of stimulation and subjective intensity of sensation. We investigated the effects of dopaminergic drug treatment (sulpiride) on the relationship between somatosensory stimulus intensity and cortical response measured electrophysiologically by somatosensory-evoked potentials (SEP) and functional magnetic resonance imaging (fMRI). The intensity of stimulation was related by a simple power law to both electrophysiological and fMRI measures of cortical response, with overlapping confidence intervals for both power law exponents. Sulpiride did not modulate the power law exponent, but significantly attenuated the "gain" of both stimulus-response functions. Using path analysis we decomposed dopaminergic effects on fMRI data into an indirect component (16%), predictable by drug effects on SEP, and a direct component (84%), not explained electrophysiologically. Results indicate that sulpiride has comparable effects on power law parameters estimated from SEP and fMRI, but fMRI has superior sensitivity to detect drug effects on somatosensory cortical recruitment by graded stimulation. (C) 2003 Elsevier Inc. All rights reserved.