Optimisation of cyclotron production parameters for the 209Bi(α, 2n) 211At reaction related to biomedical use of 211At
Optimisation of cyclotron production parameters for the 209Bi(α, 2n) 211At reaction related to biomedical use of 211At
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DOI：
10.1016/s0969-8043(00)00346-8
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发表时间：
2001-05-01
影响因子：
1.6
通讯作者：
Larsen, RH
中科院分区：
文献类型：
--
作者：
Henriksen, G;Messelt, S;Larsen, RH
研究了At-211回旋加速器α束流产生和污染物At-210束流产生与束流能量的关系。用萃取法对At-211和其他主要污染物Po-210的放射化学净化也进行了评价。为了避免杂质，以前认为28 MeV是最大束流能量，但通过使用29.1 MeV作为限制，获得了大量增加的EOB产率和提取的At-211足够的放射化学纯度。因此，更多的回旋加速器可以为临床癌症试验提供有用的数量。2001爱思唯尔科学有限公司版权所有。
The cyclotron alpha beam production of At-211 and of the contaminant At-210 related to beam energy were studied. Radiochemical purification of At-211 from the other main contaminant, Po-210, by an extraction procedure was also evaluated. To avoid impurities 28 MeV has previously been considered as a maximum beam energy, but by using instead 29.1 MeV as a limit a large increase in EOB yield and sufficient radiochemical purity of extracted At-211 were obtained. More cyclotrons could thereby deliver quantities useful for clinical cancer trials. (C) 2001 Elsevier Science Ltd. All rights reserved.