Mindfulness meditation for alcohol relapse prevention: a feasibility pilot study.
Mindfulness meditation for alcohol relapse prevention: a feasibility pilot study.
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DOI：
10.1097/adm.0b013e31816f8546
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发表时间：
2008-09
影响因子：
5.5
通讯作者：
Fleming M
中科院分区：
文献类型：
--
作者：
Zgierska A;Rabago D;Zuelsdorff M;Coe C;Miller M;Fleming M
冥想是一种很有希望的治疗酒精依赖的方法。这个为期16周的前瞻性病例系列旨在收集关于冥想预防复发疗效的初步数据，并评估研究方法的可行性。19名成人酒精依赖的毕业生参加了一个强化门诊项目。15名受试者完成了为期8周的冥想课程，并辅以在家冥想和“标准护理”治疗。结果测量包括调查和2种应激反应生物标志物。受试者（N = 19, 38.4标准差[SD] = 8.6岁）在入组时禁欲30.9 （SD = 22.2）天。完成者（N = 15）参加了82%的冥想课程，平均每周冥想4.6天（SD = 1.1）；他们在94.5% （SD = 7.4）的研究天数中戒酒，47%的人完全戒酒，47%的人重度饮酒1天或更多。他们的抑郁、焦虑、压力（P < 0.05）和渴望（P < 0.08）的严重程度，记录的复发诱因减少，正念程度增加（P < 0.05）。冥想课程被评为“非常重要”（8.7/10,SD = 1.8）和“有用的复发预防工具”（8.5/10,SD = 2.1）；参与者报告说他们“很有可能”继续冥想（9.0/10,SD = 1.5）。“获得减轻压力的技能”、“应对渴望”和“良好的团体支持”是对课程价值最常见的定性评价。与基线比较，16周时，白细胞介素-6水平降低（N = 12, P = 0.05）；皮质醇水平（N = 10）降低，但不显著。没有不良事件或副作用。冥想可能是预防酒精依赖复发的有效辅助疗法，值得进行更大规模的试验研究。研究方法适合于这样的试验。
Meditation is a promising treatment for alcohol dependence. This 16-week prospective case series was designed to gather preliminary data about the efficacy of meditation for relapse prevention and to evaluate study methods feasibility. Nineteen adult alcohol-dependent graduates of an intensive outpatient program were enrolled. Fifteen subjects completed the 8-week meditation course supplemented by at-home meditation and “standard of care” therapy. Outcome measures included surveys and 2 stress-responsive biomarkers. Subjects (N = 19, 38.4 standard deviation [SD] = 8.6-year-old) were abstinent for 30.9 (SD = 22.2) days at enrollment. Completers (N = 15) attended 82% of meditation course sessions and meditated on average 4.6 (SD = 1.1) days per week; they were abstinent on 94.5% (SD = 7.4) of study days, with 47% reporting complete abstinence and 47% reporting 1 or more heavy drinking days. Their severity of depression, anxiety, stress (P < 0.05), and craving (P < 0.08), documented relapse triggers, decreased, and the degree of mindfulness increased (P < 0.05). The meditation course was rated as a “very important” (8.7/10, SD = 1.8) and “useful relapse prevention tool” (8.5/10, SD = 2.1); participants reported being “very likely” to continue meditating (9.0/10, SD = 1.5). “Gaining skills to reduce stress,” “coping with craving,” and “good group support” were the most common qualitative comments about the course value. Compared with baseline, at 16 weeks, interleukin-6 levels decreased (N = 12, P = 0.05); cortisol levels (N = 10) were reduced but not significantly. There were no adverse events or side effects. Meditation may be an effective adjunctive therapy for relapse prevention in alcohol dependence, worthy of investigation in a larger trial. The study methods are appropriate for such a trial.