Plasma Oxytocin in Children with Autism and Its Correlations with Behavioral Parameters in Children and Parents.
Plasma Oxytocin in Children with Autism and Its Correlations with Behavioral Parameters in Children and Parents.
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DOI：
10.4306/pi.2016.13.2.174
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发表时间：
2016-03
影响因子：
2.7
通讯作者：
Ostatnikova D
中科院分区：
文献类型：
--
作者：
Husarova VM;Lakatosova S;Pivovarciova A;Babinska K;Bakos J;Durdiakova J;Kubranska A;Ondrejka I;Ostatnikova D
催产素（OT）在自闭症谱系障碍（ASD）的病因学中起着重要作用。我们的目的是找出自闭症儿童和健康儿童之间的血浆OT水平的差异，OT水平与特定自闭症症状的关联，以及特定父母自闭症特征与ASD儿童OT水平的关联。我们包括19名自闭症男孩和44名健康的年龄匹配的男孩。采用ELISA法检测OT水平。采用儿童孤独症评定量表和孤独症诊断访谈（ADI）对孤独症儿童进行评分。自闭症谱系商（AQ）、系统商（SQ）和移情商由自闭症儿童家长填写。自闭症儿童血浆OT水平显著低于对照组。OT水平与ADI互惠互动和沟通得分呈正相关。父亲的AQ和SQ与儿童血浆OT水平呈正相关。我们的研究结果支持孤独症OT缺乏的假设。孤独症儿童的OT水平与社会技能之间的“矛盾”关系表明OT系统的各个水平都存在障碍。我们首先报道了自闭症儿童的OT水平和父亲的行为测量的关联，表明OT异常停留在父母的自闭症特征和他们的孩子的自闭症症状之间。
Oxytocin (OT) has been implicated to play an important role in autism spectrum disorders (ASD) etiology. We aimed to find out the differences in plasma OT levels between children with autism and healthy children, the associations of OT levels with particular autism symptoms and the associations of particular parental autistic traits with their ASD children OT levels. We included 19 boys with autism and 44 healthy age-matched boys. OT levels were analyzed by ELISA method. Children with autism were scored by Childhood Autism Rating Scale and Autism Diagnostic Interview (ADI), adjusted research version. Autism Spectrum Quotient (AQ), Systemizing Quotient (SQ) and Empathizing Quotient were completed by parents of children with autism. Children with autism had significantly lower plasma OT levels than controls. OT levels positively correlated with ADI Reciprocal Interaction and Communication scores. AQ and SQ of fathers positively correlated with children plasma OT level. Our results support the hypothesis of OT deficiency in autism. The "paradoxical" associations of OT levels and social skills in children with autism indicate disturbances at various levels of OT system. We first reported associations of OT levels in children with autism and behavioral measures in fathers indicating that OT abnormalities stay between parental autistic traits and autism symptoms in their children.