The complexity of nanoparticle dissolution and its importance in nanotoxicological studies
The complexity of nanoparticle dissolution and its importance in nanotoxicological studies
复制标题
DOI：
10.1016/j.scitotenv.2012.08.066
复制
发表时间：
2012-11-01
影响因子：
9.8
通讯作者：
Valsami-Jones, Eugenia
中科院分区：
文献类型：
--
作者：
Misra, Superb K.;Dybowska, Agnieszka;Valsami-Jones, Eugenia
纳米粒子（NP）的溶解是改变其丰度的重要特性，并且通常是确定纳米粒子安全性的关键步骤。纳米粒子在暴露介质中的溶解状态（即它们是否保持颗粒形式或溶解 - 以及溶解程度）强烈影响纳米粒子的吸收途径、毒性机制和环境区室，其中纳米粒子将产生最大的潜在影响。对纳米颗粒现有溶出数据的审查表明，根据纳米颗粒和暴露介质的不同，存在一系列潜在结果。例如，两个名义上相同的纳米粒子，在尺寸和成分方面可能具有完全不同的溶解行为，受到不同的表面修饰。因此，必须结合纳米颗粒的溶解进行毒理学研究，以确定纳米颗粒的真实生物学效应，从而协助其调节。 (c) 2012 Elsevier B.V. 保留所有权利。
Dissolution of nanoparticles (NPs) is an important property that alters their abundance and is often a critical step in determining safety of nanoparticles. The dissolution status of the NPs in exposure media (i.e. whether they remain in particulate form or dissolve - and to what extent), strongly affects the uptake pathway, toxicity mechanisms and the environmental compartment in which NPs will have the highest potential impact. A review of available dissolution data on NPs demonstrates there is a range of potential outcomes depending on the NPs and the exposure media. For example two nominally identical nanoparticles, in terms of size and composition, could have totally different dissolution behaviours, subject to different surface modifications. Therefore, it is imperative that toxicological studies are conducted in conjunction with dissolution of NPs to establish the true biological effect of NPs and hence, assist in their regulation. (c) 2012 Elsevier B.V. All rights reserved.