Vitamin D status among long-term survivors of hematopoietic cell transplantation.
Vitamin D status among long-term survivors of hematopoietic cell transplantation.
复制标题
造血细胞移植长期幸存者的维生素 D 状况。
DOI：
10.1038/bmt.2010.326
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发表时间：
2011
影响因子：
4.8
通讯作者：
Burns,LJ
中科院分区：
文献类型：
--
作者：
Robien,K;Strayer,LG;Majhail,N;Lazovich,D;Baker,KS;Smith,AR;Mulrooney,DA;Burns,LJ
关于造血细胞移植（HCT）后血清维生素D水平知之甚少。患者被指示避免阳光照射，因为皮肤癌的风险增加。由于GVHD、胆汁酸或胰酶不足或细菌过度生长导致的胃肠道吸收能力改变可能导致难以吸收脂溶性维生素D。本研究旨在确定HCT后至少1年的儿童和成人中血清25-羟基维生素D（25（OH）D）缺乏症的患病率以及与25（OH）D缺乏症相关的因素。共有95名参与者（54名男性和41名女性）完成了一份关于日常饮食和生活方式的问卷，并在2008年11月至2009年7月期间提供了25（OH）D测定的血液样本。大多数参与者的血清25（OH）D水平<75 nmol/L（n = 62，65%），23名参与者的水平不足（50 - 75 nmol/L），10名参与者缺乏（<50 nmol/L）。大多数参与者报告定期使用维生素D补充剂（n = 58，61%）。泼尼松的使用与血清25（OH）D浓度呈显著负相关。总维生素D摄入量是25（OH）D浓度最强的单一预测因子。这些结果表明，每天400 - 600 IU维生素D似乎是必要的，以达到最佳的血清25（OH）D浓度后HCT。
Little is known about serum vitamin D levels following hematopoietic cell transplantation (HCT). Patients are instructed to avoid sun exposure because of an increased risk of skin cancers. Altered gastrointestinal absorptive capacity as a result of GVHD, bile acid or pancreatic enzyme insufficiency or bacterial overgrowth may lead to difficulty in absorbing the fat-soluble vitamin D. This study was undertaken to determine the prevalence of serum 25-hydroxyvitamin D (25 (OH) D) deficiency, and factors associated with 25 (OH) D deficiency, among children and adults who were at least 1 year following HCT. A total of 95 participants (54 males and 41 females) completed a questionnaire on usual diet and lifestyle, and provided a blood sample for 25 (OH) D determinations between November 2008 and July 2009. The majority of participants had serum 25 (OH) D levels⩾ 75 nmol/L (n= 62, 65%), 23 had insufficient levels (50–75 nmol/L) and 10 participants were deficient (< 50 nmol/L). The majority of participants reported regular use of vitamin D supplements (n= 58, 61%). Prednisone use was significantly inversely associated with serum 25 (OH) D concentrations. Total vitamin D intake was the strongest single predictor of 25 (OH) D concentrations. These findings suggest that 400–600 IU vitamin D per day appears to be required to achieve optimal serum 25 (OH) D concentrations following HCT.