Reaction Acceleration at Solid/Solution Interfaces: Katritzky Reaction Catalyzed by Glass Particles
Reaction Acceleration at Solid/Solution Interfaces: Katritzky Reaction Catalyzed by Glass Particles
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DOI：
10.1002/anie.202014613
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发表时间：
2020-12-15
影响因子：
16.6
通讯作者：
Cooks, R. Graham
中科院分区：
文献类型：
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作者：
Li, Yangjie;Mehari, Tsdale;Cooks, R. Graham
与塑料容器相比，玻璃容器的表面显著加速了室温下本体溶液中的Katritzky反应。值得注意的是，在添加玻璃颗粒时，反应速率增加了两个数量级以上，并且速率随着玻璃量的增加而线性增加。当玻璃颗粒被添加到悬浮液滴时，观察到类似的现象，其中看到大的加速因子。有证据表明，玻璃作为一种“绿色”多相催化剂：它作为碱参与去质子化步骤，并从反应混合物中原样回收。在两个单独的界面的反应加速在这项研究中被确认：i）空气/溶液相加速，如众所周知的微滴; ii）固体/溶液相，这种加速似乎是一种新的现象。
The Katritzky reaction in bulk solution at room temperature is accelerated significantly by the surface of a glass container compared to a plastic container. Remarkably, the reaction rate is increased by more than two orders of magnitude upon the addition of glass particles with the rate increasing linearly with increasing amounts of glass. A similar phenomenon is observed when glass particles are added to levitated droplets, where large acceleration factors are seen. Evidence shows that glass acts as a "green" heterogeneous catalyst: it participates as a base in the deprotonation step and is recovered unchanged from the reaction mixture. Reaction acceleration at two separate interfaces is recognized in this study: i) air/solution phase acceleration, as is well known in microdroplets; ii) solid/solution phase, where such acceleration appears to be a new phenomenon.