Ciguatera poisoning.
Ciguatera poisoning.
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DOI：
10.1136/jnnp.2007.129049
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发表时间：
2007-10-01
影响因子：
2.8
通讯作者：
Bain, Peter G
中科院分区：
文献类型：
--
作者：
Achaibar, Kira C;Moore, Simon;Bain, Peter G
雪卡中毒是食用热带和亚热带有毒雪卡鱼后发生的一种中毒形式。雪卡毒素是一类热稳定、脂溶性环状聚醚化合物，在静息膜电位下结合并打开电压敏感的Na(+)通道，导致神经过度兴奋以及朗飞结节肿胀。作者描述了安提瓜岛一名 45 岁男子在食用红鲷鱼和石斑鱼（可能具有“雪卡毒性的鱼”）后不久出现急性胃肠道症状。 24-48小时后出现神经系统症状，包括体温逆转（反常的感觉障碍）、剧烈瘙痒和小纤维周围神经病变导致的伤害感受增加。患者的症状和小纤维神经病变在 10 个月内得到改善。
Ciguatera is a form of poisoning that occurs after eating tropical and subtropical ciguatoxic fish. The ciguatoxins are a family of heat stable, lipid soluble cyclic polyether compounds that bind to and open voltage-sensitive Na(+) channels at resting membrane potential, resulting in neural hyperexcitability, as well as swelling of the nodes of Ranvier. The authors describe a 45-year-old man who developed acute gastrointestinal symptoms in Antigua soon after eating red snapper and grouper, potentially "ciguatoxic fish". This was followed by neurological symptoms 24-48 hours later, including temperature reversal (paradoxical dysaesthesia), intense pruritus and increased nociception as a result of a small fibre peripheral neuropathy. The patient's symptoms and small fibre neuropathy improved over a period of 10 months.