Plasmodesmata: a signaling hub at the cellular boundary.
Plasmodesmata: a signaling hub at the cellular boundary.
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DOI：
10.1016/j.pbi.2015.06.019
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发表时间：
2015-10
影响因子：
9.5
通讯作者：
Lee JY
中科院分区：
文献类型：
--
作者：
Lee JY
有效的细胞间通讯对于植物的生存至关重要。由于植物细胞被包裹在坚硬的细胞壁中，细胞间的细胞质内容物的直接交换只能通过胞间连丝 (PD) 来实现，胞间连丝是连接相邻细胞细胞质的膜内衬纳米管。 PD 是高度动态的通信渠道，可以进行各种结构和功能修改。该领域的最新研究结果表明，防御信号通路与 PD 的调节密切相关，而 PD 介导的细胞间通讯的限制是针对微生物病原体的关键先天免疫反应。此外，一些质膜结合信号成分，包括已知在细胞外周具有非细胞自主功能或病原体感知的受体样激酶，也被发现与帕金森病相关。这些发现暗示了 PD 作为共质和跨膜通路信号中枢的新作用。
Effective intercellular communication is crucial for the survival of plants. Because plant cells are encased in rigid cell walls, direct cell-to-cell exchange of cytoplasmic content is only possible through plasmodesmata (PD), membrane-lined nanotubes that connect the cytoplasm of adjacent cells. PD are highly dynamic communication channels that can undergo various structural and functional modifications. Recent findings in the field suggest that defense signaling pathways are tightly linked to the regulation of PD, and the restriction of PD-mediated cell-to-cell communication is a critical innate immune response to microbial pathogens. Moreover, several plasma membrane-bound signaling components, including receptor-like kinases that are known to have non-cell autonomous function or pathogen perception at the cell periphery, are found to also partition to PD. These findings hint at the novel role of PD as a signaling hub for both symplasmic and cross-membrane pathways.