Control of differentiation and cell cycling in leaf development
Control of differentiation and cell cycling in leaf development
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叶片发育过程中分化和细胞周期的控制
DOI：
10.1016/j.cbpa.2009.04.374
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Murray J
中科院分区：
文献类型：
--
作者：
Murray J
叶片发育的特征是一段有丝分裂周期，它控制发育器官中的细胞数量，随后是细胞扩张和相关的内环转换。d型细胞周期蛋白（CYCD）活性在叶片发育过程中决定这种开关的时间起着重要作用。叶片发育还需要下调分生组织标记，如SHOOTMERISTEMLESS (STM)，其持续表达促进维持未分化状态和持续的有丝分裂周期。细胞分裂素似乎密切参与决定有丝分裂状态，作用于STM的下游和CYCD活性的上游，这些因素与细胞周期控制的相互作用以及从有丝分裂周期到内环的转变将被讨论
[EN]Leaf development is characterised by a period of mitotic cycles which control the cell number in the developing organ followed by cell expansion and an associated switch to endocycles. D-type cyclin (CYCD) activity plays an important role in determining the timing of this switch during leaf development. Leaf development also requires the down-regulation of meristem markers such as SHOOTMERISTEMLESS (STM), whose continued expression promotes the maintenance of an undifferentiated state and continued mitotic cycles. Cytokinin appears to be closely involved in determining the mitotic state acting both downstream of STM and upstream of CYCD activity and the interplay of these factors with cell cycle control and the transition from mitotic cycles to endocycles will be discussed