Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy
Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy
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DOI：
10.1016/j.eplepsyres.2011.01.007
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发表时间：
2011-03-01
影响因子：
2.2
通讯作者：
Sakamoto, Americo Ceiki
中科院分区：
文献类型：
--
作者：
Freitas-Lima, Priscila;Alexandre, Veriano, Jr.;Sakamoto, Americo Ceiki
为了评估左乙拉西坦的消除是否受酶诱导抗癫痫药物（EIAED）的影响，在15名与EIAED联合用药的受试者和15名匹配的对照者中，在单次口服1000 mg剂量后频繁测定血清左乙拉西坦水平。与对照组相比，EIAED组左乙拉西坦口服清除率较高（p = 0.01），半衰期较短（p = 0.02）。虽然相互作用的程度相对较小，但对某些患者可能具有临床意义。(C)2011爱思唯尔有限公司版权所有。
To assess whether levetiracetam elimination is influenced by enzyme inducing antiepileptic drugs (EIAEDs), serum levetiracetam levels were determined at frequent intervals after a single oral 1000 mg dose in 15 subjects co-medicated with EIAEDs and 15 matched controls. The EIAED group showed a higher levetiracetam oral clearance (p = 0.01) and a shorter half-life (p = 0.02) than controls. Although the magnitude of interaction is relatively modest, it could have clinical significance for some patients. (C) 2011 Elsevier B.V. All rights reserved.