Postmortem Quantitative Analysis of Prion Seeding Activity in the Digestive System
Postmortem Quantitative Analysis of Prion Seeding Activity in the Digestive System
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DOI：
10.3390/molecules24244601
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发表时间：
2019-12
期刊：
影响因子：
4.6
通讯作者：
K. Satoh;T. Fuse;T. Nonaka;Trong Dong;M. Takao;Takehiro Nakagaki;D. Ishibashi;Yuzuru Taguchi
中科院分区：
文献类型：
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作者：
K. Satoh;T. Fuse;T. Nonaka;Trong Dong;M. Takao;Takehiro Nakagaki;D. Ishibashi;Yuzuru Taguchi
人类朊病毒病是由朊病毒蛋白引起的神经退行性疾病。尽管历史上仅在散发性克雅氏病患者的中枢神经系统和淋巴网状组织中检测到感染性，但最近的报告表明，克雅氏病朊病毒的播种活性在各种非神经元器官中积累，包括肝脏、肾脏和皮肤。因此，我们重新分析了从散发性和遗传性人类朊病毒病患者身上收集的尸检样本，发现几乎所有消化器官都存在播种活性。出乎意料的是，一些克雅氏病患者食道中的朊病毒播种活动达到了接近中枢神经系统的朊病毒播种活动水平，这表明应重新考虑内镜检查的安全性。
Human prion diseases are neurodegenerative disorders caused by prion protein. Although infectivity was historically detected only in the central nervous system and lymphoreticular tissues of patients with sporadic Creutzfeldt-Jakob disease, recent reports suggest that the seeding activity of Creutzfeldt-Jakob disease prions accumulates in various non-neuronal organs including the liver, kidney, and skin. Therefore, we reanalyzed autopsy samples collected from patients with sporadic and genetic human prion diseases and found that seeding activity exists in almost all digestive organs. Unexpectedly, activity in the esophagus reached a level of prion seeding activity close to that in the central nervous system in some CJD patients, indicating that the safety of endoscopic examinations should be reconsidered.