The relationship between orofacial clefts and material deprivation in Wales
The relationship between orofacial clefts and material deprivation in Wales
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DOI：
10.1597/06-004.1
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发表时间：
2007-03-01
期刊：
影响因子：
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通讯作者：
Lester, N. J.
中科院分区：
文献类型：
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作者：
Durning, P.;Chestnutt, I. G.;Lester, N. J.
目的：本研究探讨了英国威尔士南部、西部和中部的物质剥夺与口面裂（OFC）发生率的关系。设计与背景：威尔士南部、西部和中部的口面裂登记册作为本研究的主要数据来源。1982年至2003年间出生的所有唇腭裂儿童的数据被地理编码到844个地理病房中的一个。同样经过地理编码的全国人口普查数据作为人口分母。汤森的物质剥夺指数用于将病房划分为七个剥夺程度之一。这允许调查与物质剥夺的口面裂隙的关系。结果：1982年至2003年期间，有831名婴儿出生时患有口面部裂，相当于每10万活产婴儿中有109名唇裂。唇腭裂的发生率从82 / 100,000(95%可信区间[C.I.]生活在最贫困地区的母亲所生婴儿的死亡率为64至102 / 10万)，而生活在最贫困地区的母亲所生婴儿的死亡率为127 / 10万（95% ci， 112至144 / 10万），显著的线性趋势很明显（p < .001）。在剥夺程度最高和剥夺程度最低的鼻中隔之间，发生口面沟裂的风险为1.55 (95% ci， 1.18至2.04)，具有统计学意义。结论：本研究进一步证明了物质剥夺与口面裂隙之间的关系。需要进一步的工作来引出潜在的风险因素在多大程度上促成了这种联系，并确定剥夺是如何导致唇腭裂的。
Objective: This study investigated the relationship between material deprivation and the incidence of orofacial clefts (OFC) in South, West, and Central Wales, U.K.Design and Setting: The South, West, and Central Wales Orofacial-Cleft Register served as the primary data source for the study. Data on all children born with an orofacial cleft between 1982 and 2003 were geocoded to one of 844 geographic wards. National census data, similarly geocoded, served as the population denominator. Townsend's index of material deprivation was used to assign wards to one of seven levels of deprivation. This permitted investigation of the association of orofacial clefts with material deprivation.Results: Between 1982 and 2003, there were 831 babies born with an orofacial cleft, equating to 109 clefts per 100,000 live births. The incidence of orofacial clefts ranged from 82 per 100,000 (95% confidence interval [C.I.] 64 to 102 per 100,000) in babies born to mothers residing in the least deprived areas to 127 per 100,000 (95% C.I., 112 to 144 per 100,000) in those living in the most deprived areas, a significant linear trend being apparent (p < .001). A statistically significant risk of 1.55 (95% C.I., 1.18 to 2.04) for orofacial clefts was apparent between most and least deprived septiles of deprivation.Conclusions: This study provides further evidence of an association between material deprivation and orofacial clefts. Further work is required to elicit the degree to which potential risk factors contribute to this association and to determine how deprivation predisposes to orofacial clefts.