Sulfation of glycolipids by human gastric mucosa in disease.
Sulfation of glycolipids by human gastric mucosa in disease.
复制标题
疾病中人体胃粘膜对糖脂的硫酸化。
作者：
Slomiany,BL;Liau,YH;Sarosiek,J;Tsukada,H;Mizuta,K;Rosenthal,W;Slomiany,A
在重度和慢性胃炎、胃萎缩、胃溃疡和胃癌患者的胃底和胃窦粘膜活检中，研究了参与将硫酸盐从3 '-磷酸腺苷5'-磷酸硫酸盐转移到粘膜和粘液凝胶糖脂的磺基转移酶的活性水平。与磺基转移酶催化粘液的硫酸化三葡糖基甘油葡萄糖脂的酶活性增加超过对照组中观察到慢性和严重的胃炎，胃萎缩，而活性下降，在胃溃疡和胃癌患者中注意到。重度胃炎、胃溃疡和胃癌的差异有显著性（P < 0.001）。在所有患者的胃窦和胃底粘膜中观察到参与膜半乳糖神经酰胺硫酸化的磺基转移酶活性增加。重度胃炎、胃萎缩和胃溃疡患者之间有显著性差异（P < 0.001）。结果表明，相当大的变化，在活动的粘膜磺基转移酶参与膜和分泌型硫脂的合成发生在胃病。
The activity levels of sulfotransferase enzymes involved in the transfer of sulfate from 3’-phosphoadenosine 5’-phosphosulfate to mucosal membrane and mucus gel glycolipids were studied in fundic and antral mucosal biopsies of patients with severe and chronic gastritis, gastric atrophy, gastric ulcer, and gastric cancer. With sulfotransferase which catalyzes the sulfation of mucus triglucosyl glyceroglucolipid increase in enzyme activity over the control was observed in patients with chronic and severe gastritis, and gastric atrophy, while a decrease in activity was noted in patients with gastric ulcer and gastric cancer. The differences were significant at p < 0.001 for severe gastritis, gastric ulcer and gastric cancer. The increase in activity of sulfotransferase enzyme involved in the sulfation of membrane galactosylceramide over the control was observed in antral and fundic mucosa of all patients. Significant (p < 0.001) differences were found in patients with severe gastritis, gastric atrophy and gastric ulcer. The results indicate that considerable changes in the activities of the mucosal sulfotransferase enzymes involved in the synthesis of membrane and secretory sulfolipids occur in gastric disease.