Efficient Synthesis of Isoquinolines by AgNO3‐Catalyzed Sequential Imination‐Annulation of 2‐Alkynyl Aldehydes with Ammonium Bicarbonate
Efficient Synthesis of Isoquinolines by AgNO3‐Catalyzed Sequential Imination‐Annulation of 2‐Alkynyl Aldehydes with Ammonium Bicarbonate
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DOI：
10.1002/cjoc.201600277
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发表时间：
2016-09
影响因子：
5.4
通讯作者：
Yunhui Zhao;Mingjian Luo;Yubo Li;Xiongli Liu;Zi-long Tang;Keqin Deng;Gang Zhao
中科院分区：
文献类型：
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作者：
Yunhui Zhao;Mingjian Luo;Yubo Li;Xiongli Liu;Zi-long Tang;Keqin Deng;Gang Zhao
介绍了一种操作简单的方法，通过邻炔醛和碳酸氢铵的反应，通过银催化的6位内二取代环的闭合，串联合成异喹啉。考察了反应条件和反应范围，并以中等至优异的产率制备了多种取代的异喹啉。
An operationally simple approach for the tandem synthesis of isoquinolines by the reaction ofo‐alkynylaldehydes with ammonium bicarbonateviaAg‐catalyzed 6‐endo‐dig ring closure is described. The reaction conditions and the scope of the reaction are examined, and a variety of substituted isoquinolines are prepared in moderate to excellent yields.