Clinical trial of home available, mixed diets versus a lactose-free, soy-protein formula for the dietary management of acute childhood diarrhea.
Clinical trial of home available, mixed diets versus a lactose-free, soy-protein formula for the dietary management of acute childhood diarrhea.
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家庭混合饮食与无乳糖大豆蛋白配方食品治疗急性儿童腹泻的临床试验。
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发表时间：
1991
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影响因子：
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通讯作者：
Kenneth H Brown
中科院分区：
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作者：
Pedro Alarcon;Ramon Montoya;F. Pérez;J. W. Dongo;J. Peerson;Kenneth H Brown
完成了一项随机临床试验，以研究85名5至24个月的秘鲁儿童急性腹泻的严重程度、持续时间和营养结果，这些儿童接受了大豆分离蛋白、无乳糖配方奶粉（SF组）或两种家庭可用食物的混合物之一，所有食物的摄入量均高达110千卡/千克体重/天。混合饲料含有小麦粉、豌豆粉、胡萝卜粉、蔗糖和植物油（WP组）或马铃薯粉、全脂奶粉、胡萝卜粉、蔗糖和油（PM组）。两组儿童的特征在开始时基本相似。不同饮食组的治疗失败率无差异。给药第1天，所有组的粪便排出量相似，平均为60 - 65 g/kg/天。然而，PM组在第3天和第4天的粪便排出量大于其他组，SF组在第5天和第6天的粪便排出量小于其他组。WP组（52 h）和PM组（53 h）的腹泻估计中位持续时间显著短于SF组（154 h，p = 0.005）。能量摄入量，能量吸收，氮保留（%摄入量）在所有饮食组中大致相似，虽然有特定的常量营养素的吸收略有差异。所有组的儿童在住院期间体重增加，并且在治疗期间，饮食组的人体测量状态变化没有显著差异。我们的结论是，这些当地可用的低成本主食混合物为商业生产的无乳糖配方奶粉提供了安全且营养充足的替代品，可用于这种情况下患有急性腹泻的幼儿的饮食管理。
A randomized clinical trial was completed to study the severity, duration, and nutritional outcome of acute diarrhea in 85 Peruvian children between 5 and 24 months of age who received a soy-protein-isolate, lactose-free formula (group SF) or one of two mixtures of home-available foods, all in amounts up to 110 kcal/kg of body weight/day. The mixed diets contained either wheat flour, pea flour, carrot flour, sucrose, and vegetable oil (group WP) or potato flour, dried whole milk, carrot flour, sucrose, and oil (group PM). The characteristics of the children in each group were generally similar initially. There were no differences in treatment failure rate by diet group. Fecal outputs were similar in all groups during the first day of treatment, averaging 60 to 65 g/kg/day. However, stool outputs were greater for the PM group than for other groups on days 3 and 4, and were less for the SF group than the other groups on days 5 and 6. The estimated median durations of diarrhea in the WP group (52 h) and PM group (53 h) were significantly less than in the SF group (154 h, p = 0.005). Energy intakes, energy absorption, and nitrogen retention (% of intake) were generally similar in all dietary groups, although there were minor differences in the absorption of specific macronutrients. Children in all groups gained weight during hospitalization, and there were no significant differences by diet group in the change in anthropometric status during treatment. We conclude that these locally available, low-cost staple food mixtures offer a safe and nutritionally adequate alternative to a commercially produced lactose-free formula for the dietary management of young children with acute diarrhea in this setting.