Atrial natriuretic peptide blocks renin response to renal hypotension.
Atrial natriuretic peptide blocks renin response to renal hypotension.
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心钠素可阻断肾素对肾性低血压的反应。
DOI：
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发表时间：
1987
影响因子：
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通讯作者：
D. Ramsay
中科院分区：
文献类型：
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作者：
D. Scheuer;T. Thrasher;E. Quillen;C. Metzler;D. Ramsay
我们曾报道，在心房压升高的情况下，肾素对全身性低血压的反应受到抑制，并且心房压升高相似或更大幅度会导致血浆心钠素（ANP）分级升高。因此，我们测试的假设，血浆心钠素的可比增量可以抑制肾功能不全引起的血浆肾素活性（PRA）在清醒的狗增加。肾灌注压通过在肾动脉正上方的腹主动脉周围植入袖带控制。肾灌注压降低10%或30%，PRA呈递增趋势（P <0.01）。注射1-28只大鼠ANP（5 ng × kg ~（-1）× min ~（-1））可使血浆ANP增加34.8 ± 7.5（SE）pg/ml，消除了对肾灌注压降低10%的反应的PRA增加，并显著抑制了对肾灌注压降低30%的反应（P <0.01）。这些结果表明，增加血浆心钠素，再现内源性释放抑制肾水肿引起的PRA的刺激。此外，这些结果提供了一个解释，在心房压力升高时，抑制肾性低血压的肾素反应。
We have reported that the renin response to systemic hypotension is inhibited in the presence of elevated atrial pressure and that elevations in atrial pressure of similar or larger magnitude cause graded increases in plasma atrial natriuretic peptide (ANP). Therefore we tested the hypothesis that comparable increments in plasma ANP can inhibit renal hypotension-induced increases in plasma renin activity (PRA) in conscious dogs. Renal perfusion pressure was controlled using cuffs implanted around the abdominal aorta just above the renal arteries. Reducing renal perfusion pressure by 10 or 30% of control caused graded increases in PRA (P less than 0.01). Infusion of 1-28 rat ANP (5 ng X kg-1 X min-1), which increased plasma ANP by 34.8 +/- 7.5 (SE) pg/ml, eliminated increases in PRA in response to a 10% reduction in renal perfusion pressure and markedly inhibited the response to a 30% pressure reduction (P less than 0.01). These results indicate that increments in plasma ANP which reproduce endogenous release inhibit renal hypotension-induced stimulation of PRA. Furthermore, the results provide an explanation for the inhibition of the renin response to renal hypotension during elevated atrial pressure.