GLOBOSE BASAL CELLS ARE NEURONAL PROGENITORS IN THE OLFACTORY EPITHELIUM - A LINEAGE ANALYSIS USING A REPLICATION-INCOMPETENT RETROVIRUS
GLOBOSE BASAL CELLS ARE NEURONAL PROGENITORS IN THE OLFACTORY EPITHELIUM - A LINEAGE ANALYSIS USING A REPLICATION-INCOMPETENT RETROVIRUS
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DOI：
10.1016/0896-6273(94)90351-4
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发表时间：
1994-08-01
期刊：
影响因子：
16.2
通讯作者：
HUNTER, DD
中科院分区：
文献类型：
--
作者：
CAGGIANO, M;KAUER, JS;HUNTER, DD
我们已经使用了一种复制能力低下的逆转录病毒来分析年轻大鼠嗅觉受体神经元的谱系。在感染后5-40天，受感染的细胞簇包括两种主要类型：一种由1-2个水平基底细胞组成，第二种由可变数量的球状基底细胞和未成熟和成熟的感觉神经元组成。嗅神经损伤（其增强神经元更新）增加了球状感觉神经元簇的频率以及此类簇中的细胞数量。没有集群包含水平和球形的基底细胞，没有包含支持细胞。这些数据表明，至少在年轻的大鼠，水平基底细胞的嗅觉神经元的前体，有一个谱系路径从球状细胞成熟的神经元，和支持细胞可能出现从一个单独的谱系。
We have used a replication-incompetent retrovirus to analyze the lineage of olfactory receptor neurons in young rats. At 5-40 days after infection, clusters of infected cells comprised two major types: one consisted of 1-2 horizontal basal cells, and a second consisted of variable numbers of globose basal cells and immature and mature sensory neurons. Olfactory nerve lesion (which enhances neuronal turnover) increased the frequency of the globose-sensory neuron clusters as well as the number of cells in such clusters. No clusters contained both horizontal and globose basal cells, and none contained sustentacular cells. These data suggest, at least in young rats, that horizontal basal cells are not precursors of olfactory neurons, that there is a lineage path from globose cells to mature neurons, and that sustentacular cells may arise from a separate lineage.