CELL-TYPES AND MORPHOGENESIS IN THE MAMMARY-GLAND

CELL-TYPES AND MORPHOGENESIS IN THE MAMMARY-GLAND
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DOI：
10.1073/pnas.79.23.7346
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发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
通讯作者：
ARMSTRONG, B
ARMSTRONG, B
中科院分区：
其他
文献类型：
--
作者：
DULBECCO, R;HENAHAN, M;ARMSTRONG, B

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通过在发情周期的各个阶段用放射性胸苷标记雌性大鼠，研究了乳腺中存在的细胞类型及其演变。显然，乳腺发育的干细胞存在于终末芽中，它们产生管腔细胞的谱系，并可能产生肌上皮细胞的独特谱系。生长和分化受激素和局部因素的控制。
Cell types present in the mammary gland and their evolution were studied by labeling female rats with radioactive thymidine at various phases of the estrous cycle. Apparently the stem cells for mammary development are present in the terminal end buds and they generate a lineage for luminal cells and possibly a distinct one for myoepithelial cells. Growth and differentiation are controlled by both hormones and local factors.