Estimation of tissue volume from serial tomographic sections. A statistical random marking method.
Estimation of tissue volume from serial tomographic sections. A statistical random marking method.
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根据连续断层扫描切片估计组织体积。
DOI：
10.1097/00004424-198810000-00008
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发表时间：
1988
影响因子：
6.7
通讯作者：
Karwoski,RA
中科院分区：
文献类型：
--
作者：
Bentley,MD;Karwoski,RA
已用于测量连续计算机断层摄影切片中选定组织的体积的计算机操作员交互式平面测量方法非常耗时，并且测量的准确性受到操作员描绘组织轮廓的技能的限制。我们引入了一种替代方法，该方法比平面测量法快 5 到 6 倍，并且与操作员勾画轮廓的灵巧程度无关。该方法涉及在已知大小的三维阵列中随机标记体素，并随后识别感兴趣组织内的那些体素的比例。使用高速体积扫描计算机 X 射线断层扫描成像系统对肾脏和左心室心肌组织进行原位成像。通过随机标记方法进行的体积测量与通过面积测量法和死后重量进行的测量高度相关（r = 0.99）。这些数据表明，随机标记方法提供了一种快速、准确地估计连续断层扫描切片中的组织体积的方法。
Computer operator-interactive planimetric methods that have been employed to measure volume of a selected tissue in serial computed tomographic sections are time consuming, and the accuracy of the measurement is limited by the operator's skill in outlining the tissue. We introduce an alternate method that is 5 to 6 times faster than planimetry and is independent of the operator's outlining dexterity. This method involves the random marking of voxels in a three-dimensional array of known size and subsequent identification of the proportion of those voxels that are within the tissue of interest. Tissue of the kidney and left ventricular myocardium were imaged in situ with a high speed, volume scanning, computerized x-ray tomographic imaging system. Volumetric measurements made by the random marking method correlatedhighly (r= 0.99) with measurements made by planimetry and with postmortem weight. These data indicate that the random marking method provides a rapid and accurate means of estimating tissue volume in serial tomographic sections.