Influence of premature rupture of membrane on the cerebral blood flow in low-birth-weight infant after the delivery
Influence of premature rupture of membrane on the cerebral blood flow in low-birth-weight infant after the delivery
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DOI：
10.1016/j.braindev.2009.09.023
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发表时间：
2010-09-01
影响因子：
1.7
通讯作者：
Goto, Haruo
中科院分区：
文献类型：
--
作者：
Fukuda, Sumio;Yokoi, Kyoko;Goto, Haruo
脑白色物质损伤，通常称为脑室周围白质软化症（PVL），是早产儿最常见的损伤形式，与不良运动和认知结果相关。宫内感染可能是PVL的重要病因，胎膜早破（PROM）可在产前发现。为探讨胎膜早破所致脑白色损害的病理生理机制，应用颈部超声检测了胎膜早破大鼠颈内动脉和椎动脉的脑血流量。对84例胎龄24 ~ 35周的低出生体重儿进行了脑血流量测定，其中无胎膜早破71例，胎膜早破13例。于出生后0 ~ 70天测量各血管的平均血流速度和直径。通过计算平均血流速度和横截面积来确定血管内流量。记录平均血压，并测定射血分数。胎膜早破组10 ~ 70天的脑血流量明显低于非胎膜早破组。在第0、5、10、21和42天，胎膜早破婴儿的射血分数显著高于无胎膜早破婴儿。有胎膜早破的婴儿和无胎膜早破的婴儿的平均血压没有差异。本研究结果提示，胎膜早破可降低产后脑血流量。(C)2009 Elsevier B. V.保留所有权利。
Cerebral white matter injury, usually called periventricular leukomalacia (PVL), is the most common form of injury to preterm infants that is associated with adverse motor and cognitive outcomes. Intrauterine infection may be an important etiological factor in PVL, and premature rupture of the membranes (PROM) can be identified antepartum. In order to investigate the pathophysiology of cerebral white matter injury induced by PROM, the cerebral blood flow (CBF) of the internal carotid artery and the vertebral artery was measured by neck ultrasonography. The CBF was determined in 84 low-birth-weight infants with gestational ages ranging from 24 to 35 weeks, including 71 infants without PROM and 13 infants with PROM. The mean blood flow velocity and diameter of each vessel were measured on postnatal days 0-70. The intravascular flow volume was determined by calculating the mean blood flow velocity and the cross-sectional area. The mean blood pressures were recorded, and the ejection fraction was determined. The total cerebral blood flow (CBF) was significantly lower in infants with PROM than in infants without PROM from day 10 to day 70. The ejection fraction was significantly higher in infants with PROM than in infants without PROM on days 0, 5, 10, 21, and 42. There was no difference in the mean blood pressure between infants with PROM and infants without PROM. The results of the present study suggest that PROM may decrease cerebral blood flow after the birth. (C) 2009 Elsevier B.V. All rights reserved.