Dietary acetic acid reduces serum cholesterol and triacylglycerols in rats feda cholesterol-rich diet
Dietary acetic acid reduces serum cholesterol and triacylglycerols in rats feda cholesterol-rich diet
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DOI：
10.1079/bjn20061740
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发表时间：
2006-05-01
影响因子：
3.6
通讯作者：
Goda, T
中科院分区：
文献类型：
--
作者：
Fushimi, T;Suruga, K;Goda, T
为了研究摄入醋预防胆固醇血症的功效，我们研究了饮食中醋酸（醋的主要成分）对喂食含1%（w/w）胆固醇饮食的大鼠血脂值的影响。允许动物自由摄入不含胆固醇的饲料、含1%胆固醇但不含醋酸的饲料或含1%胆固醇和0.3%（w/w）醋酸的饲料，持续19天。禁食7 h后处死。胆固醇喂养增加血清总胆固醇和三酰甘油水平。与胆固醇组相比，胆固醇和乙酸组血清总胆固醇和三酰甘油、肝脏ATP柠檬酸裂解酶（ATP-CL）活性、肝脏3-羟基-3-甲基戊二酰辅酶A含量以及肝脏固醇调节元件结合蛋白-1、ATP-CL和脂肪酸合成酶的mRNA水平显著降低（P < 0.05）。此外，胆固醇和乙酸组的血清促胰液素水平、肝脏酰基辅酶A氧化酶表达和粪便胆汁酸含量显著高于胆固醇组（P < 0.05）。然而，乙酸喂养既不影响mRNA水平，也不影响胆固醇7 α-羟化酶的活性。总之，膳食乙酸降低血清总胆固醇和三酰甘油：首先是由于抑制肝脏中的脂肪生成;其次是由于在大鼠粪便胆汁酸排泄的增量喂养的饮食中含有胆固醇。
To investigate the efficacy of the intake of vinegar for prevention of hyperlipidaemia, we examined the effect of dietary acetic acid, the main component of vinegar, on serum lipid values in rats fed a diet containing 1% (w/w) cholesterol. Animals were allowed free access to a diet containing no cholesterol, a diet containing 1% cholesterol without acetic acid, or a diet containing 1 % cholesterol with 0.3% (w/w) acetic acid for 19 d. Then, they were killed after food deprivation for 7 h. Cholesterol feeding increased serum total cholesterol and triacylglycerol levels. Compared with the cholesterol-fed group, the cholesterol and acetic acid-fed group had significantly lower values for serum total cholesterol and triacylglycerols, liver ATP citrate lyase (ATP-CL) activity, and liver 3-hydroxy-3-methylglutaryl-CoA content as well as liver mRNA levels of sterol regulatory element binding protein-1, ATP-CL and fatty acid synthase (P < 0.05). Further, the serum secretin level, liver acyl-CoA oxidase expression, and faecal bile acid content were significantly higher in the cholesterol and acetic acid-fed group than in the cholesterol-fed group (P < 0.05). However, acetic acid feeding affected neither the mRNA level nor activity of cholesterol 7 alpha-hydroxylase. In conclusion, dietary acetic acid reduced serum total cholesterol and triacylglycerol: first due to the inhibition of lipogenesis in liver; second due to the increment in faecal bile acid excretion in rats fed a diet containing cholesterol.