An easily accessible Web-based minimization random allocation system for clinical trials.
An easily accessible Web-based minimization random allocation system for clinical trials.
复制标题
DOI：
10.2196/jmir.2392
复制
发表时间：
2013-07-19
影响因子：
7.4
通讯作者：
Ma J
中科院分区：
文献类型：
--
作者：
Xiao L;Huang Q;Yank V;Ma J
Minimization as an adaptive allocation technique has been recommended in the literature for use in randomized clinical trials. However, it remains uncommonly used due in part to a lack of easily accessible implementation tools. To provide clinical trialists with a robust, flexible, and readily accessible tool for implementing covariate-adaptive biased-coin randomization. We developed a Web-based random allocation system, MinimRan, that applies Pocock–Simon (for trials with 2 or more arms) and 2-way (currently limited to 2-arm trials) minimization methods for trials using only categorical prognostic factors or the symmetric Kullback–Leibler divergence minimization method for trials (currently limited to 2-arm trials) using continuous prognostic factors with or without categorical factors, in covariate-adaptive biased-coin randomization. In this paper, we describe the system’s essential statistical and computer programming features and provide as an example the randomization results generated by it in a recently completed trial. The system can be used in single- and double-blind trials as well as single-center and multicenter trials. We expect the system to facilitate the translation of the 3 validated random allocation methods into broad, efficient clinical research practice.
登录
查看更多内容
影响因子：
39
作者：
Ma, Jun;Yank, Veronica;Stafford, Randall S.
通讯作者：
Stafford, Randall S.
影响因子：
2.7
作者：
EFRON, B
通讯作者：
EFRON, B
网络上通用的最小化随机分配和致盲系统
影响因子：
4.5
作者：
Cai, Hongwei;Xia, Jielai;Yan, Yongping
通讯作者：
Yan, Yongping
DOI：
10.1016/s0169-2607(99)00047-4
发表时间：
2000-05-01
影响因子：
6.1
作者：
Kenjo, Y;Antoku, Y;Nose, Y
通讯作者：
Nose, Y
影响因子：
4
作者：
Carter, Ben R.;Hood, Kerenza
通讯作者：
Hood, Kerenza