The prevalence of mtDNA4977 deletion in primary human endometrial carcinomas and matched control samples
The prevalence of mtDNA4977 deletion in primary human endometrial carcinomas and matched control samples
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DOI：
10.3892/or_00000060
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发表时间：
2008-09-01
期刊：
影响因子：
4.2
通讯作者：
Semczuk, Andrzej
中科院分区：
文献类型：
--
作者：
Futyma, Konrad;Putowski, Lechoslaw;Semczuk, Andrzej
mtDNA 4977是最常见的线粒体DNA缺失，已在不同类型的人类肿瘤中检测到。本研究的目的是确定原发性子宫内膜癌（EC）中mtDNA（4977）缺失的患病率，并与匹配的对照样本进行比较。37个匹配的对照组织和EC样本入组，并使用基于PCR的技术研究4977 bp mtDNA缺失。37例对照组中有32例（84%）线粒体DNA缺失（4977），37例内皮细胞中有30例（81%）线粒体DNA缺失。正常子宫内膜组织和子宫内膜癌组织中mtDNA（4977）/野生型mtDNA比值的相关性有统计学意义（R=0.844，p
mtDNA4977, the most common deletion of the mitochondrial DNA, has been detected in different types of human neoplasia. The aim of the current study was to determine the prevalence of mtDNA(4977) deletion in primary human endometrial carcinomas (EC) as compared with matched control samples. Thirty-seven matched control tissues and EC samples were enrolled, and the 4977-bp mtDNA deletion was investigated using a PCR-based technique. Deletion of mtDNA(4977) was detected in 32 out of 37 (84%) matched control samples and in 30 out of 37 (81%) ECs. A statistically significant correlation of mtDNA(4977)/wild-type mtDNA ratios was noted between normal and cancerous human endometrial tissues (R=0.844, p