Basal-to-apical cadherin flow at cell junctions
Basal-to-apical cadherin flow at cell junctions
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DOI：
10.1038/ncb1520
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发表时间：
2007-01-01
影响因子：
21.3
通讯作者：
Takeichi, Masatoshi
中科院分区：
文献类型：
--
作者：
Kametani, Yoshiko;Takeichi, Masatoshi
稳定的细胞-细胞粘附对于维持组织完整性至关重要，但细胞也能够重新定位，这意味着存在协调细胞粘附和运动的机制。在这里，我们发现，在一些转化细胞系中，钙粘蛋白粘附分子在细胞连接处表现出基顶方向的流动，这种流动与肌动蛋白丝的重组有关。这种流动也发生在正常的上皮层中，但仅发生在运动细胞形成的连接处。我们提出，钙粘蛋白流动可能提供了一种机制，促进两个接触细胞膜在形态上活跃的细胞片上的滑动。
Stable cell-cell adhesion is essential for maintaining tissue integrity, but cells are also able to relocate, implying the existence of mechanisms for coordinating cell adhesion and movement. Here, we show that, in some transformed lines, cadherin adhesion molecules exhibit a flow-like movement in a basal-apical direction at the cell junction and that this flow is associated with reorganizing actin filaments. Such flow also occurs in normal epithelial sheets, but solely at the junctions formed by moving cells. We propose that cadherin flow may provide a mechanism for facilitating the sliding of the two contacting cell membranes in morphogenetically active cell sheets.