Macroscopic classification of superficial neoplastic lesions of the oral mucosa: A preliminary study
Macroscopic classification of superficial neoplastic lesions of the oral mucosa: A preliminary study
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DOI：
10.1016/j.ejso.2007.02.032
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发表时间：
2008-01-01
期刊：
影响因子：
3.8
通讯作者：
Mignogna, M. D.
中科院分区：
文献类型：
--
作者：
Fedele, S.;Lo Russo, L.;Mignogna, M. D.
背景资料：胃肠道浅表肿瘤肉眼外观的仔细内镜分类对于癌症的早期发现和适当治疗至关重要。它有助于引入微创内窥镜手术，并显著提高了结肠癌和胃癌患者的生存率。口腔鳞状细胞癌的特点是，在过去和现在，预后差，缺乏进展的治疗结果。口腔恶性肿瘤的早期诊断失败是一个主要原因，并且缺乏一个世界范围内采用的宏观外观分类，类似于胃肠道肿瘤，可能是导致这一问题的原因。为了检验这一假设，即有可能将基于消化道浅表肿瘤的肉眼外观的分类的诊断益处扩展到口腔浅表癌。mucosa.Methods:我们回顾性研究了一组发生多发性上皮内和早期浸润性恶性口腔肿瘤的患者，采用改良版的巴黎浅表胃肠道肿瘤病变分类。（94.9%）的研究病灶的形态学特征符合所编制的分类。这些初步数据表明，大多数口腔浅表早期肿瘤病变可以很容易地检测到使用一个明确的分类系统，类似于在诊断早期胃肠道恶性肿瘤。(c)2007爱思唯尔有限公司保留所有权利。
Background: Careful endoscopic classification of macroscopic appearance of superficial neoplasias of the gastrointestinal tract is essential in the early detection and appropriate treatment of cancer. It has contributed to introduce minimally invasive endoscopic surgery and has significantly improved survival of patients with colon and gastric cancers. Squamous cell carcinoma of the oral cavity has been characterized, in past and present times, by poor prognosis and lack of progress in treatment outcome. Failure in diagnosing oral malignancy at an early stage is a major culprit, and the lack of a worldwide adopted classification of its macroscopic appearance, similar to that of gastrointestinal neoplasias, may have contributed to it.Aim: To test the hypothesis that is possible to extend the diagnostic benefit of a classification based upon the macroscopic appearance of superficial tumours of the digestive tract to superficial carcinoma of the oral mucosa.Methods: We retrospectively examined a group of patients who developed multiple intraepithelial and early invasive malignant oral neoplasias, applying a modified version of the Paris classification of superficial GI neoplastic lesions.Results: One hundred and ten out of 116 (94.9%) of the study lesions had morphological features that accorded with the prepared classification.Conclusions: These preliminary data suggest that most superficial early neoplastic lesions of the oral cavity can be easily detected using a well-defined classification system similar to that employed in the diagnosis of early gastrointestinal malignancy. (c) 2007 Elsevier Ltd. All rights reserved.