Alcohol, drinking pattern and all-cause, cardiovascular and alcohol-related mortality in Eastern Europe.
Alcohol, drinking pattern and all-cause, cardiovascular and alcohol-related mortality in Eastern Europe.
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DOI：
10.1007/s10654-015-0092-8
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发表时间：
2016-01
影响因子：
13.6
通讯作者：
Marmot MG
中科院分区：
文献类型：
--
作者：
Bobak M;Malyutina S;Horvat P;Pajak A;Tamosiunas A;Kubinova R;Simonova G;Topor-Madry R;Peasey A;Pikhart H;Marmot MG
酒精与中欧和东欧的高死亡率有关，但其影响的程度，以及它是由于经常性的高摄入量还是间歇性的暴饮暴食仍不清楚。本文的目的是估计酒精对四个中欧和东欧国家死亡率的影响。我们使用的数据来自东欧的健康、酒精和心理社会因素，这是一项在新西伯利亚（俄罗斯）、克拉科夫（波兰）、考纳斯（立陶宛）和6个捷克城镇进行的前瞻性多中心队列研究。在2002-2005年期间，对34 304名年龄在45-69岁之间的男性和女性进行了中位7年的随机人口样本随访。饮酒量，频率和模式估计从分级频率问卷。通过死亡登记册确定死亡人数。在230，246人年的随访中，2895名参与者死于各种原因，1222名死于心血管疾病（CVD），672名死于冠心病（CHD），489名死于预定义的酒精相关原因（ARD）。在完全调整的模型中，与轻度至中度饮酒者相比，戒酒者的死亡风险增加了30- 50%。平均饮酒≥60 g/天的男性（3%的男性）校正后的全因风险比（HR）为1.23（95% CI 0.95-1.59），CVD为1.38（0.95-2.02），CHD为1.64（1.02-2.64），ARD死亡率为2.03（1.28-3.23）。平均饮酒量≥20 g/d的女性（2%的女性）相应的HR分别为1.92（1.25-2.93）、1.74（0.76-3.99）、1.39（0.34-5.76）和3.00（1.26-7.10）。酗酒仅增加男性ARD死亡率。死亡率与高平均酒精摄入量相关，但与狂饮无关，男性ARD除外。本文的在线版本（doi：10.1007/s10654-015-0092-8）包含补充材料，可供授权用户使用。
Alcohol has been implicated in the high mortality in Central and Eastern Europe but the magnitude of its effect, and whether it is due to regular high intake or episodic binge drinking remain unclear. The aim of this paper was to estimate the contribution of alcohol to mortality in four Central and Eastern European countries. We used data from the Health, Alcohol and Psychosocial factors in Eastern Europe is a prospective multi-centre cohort study in Novosibirsk (Russia), Krakow (Poland), Kaunas (Lithuania) and six Czech towns. Random population samples of 34,304 men and women aged 45–69 years in 2002–2005 were followed up for a median 7 years. Drinking volume, frequency and pattern were estimated from the graduated frequency questionnaire. Deaths were ascertained using mortality registers. In 230,246 person-years of follow-up, 2895 participants died from all causes, 1222 from cardiovascular diseases (CVD), 672 from coronary heart disease (CHD) and 489 from pre-defined alcohol-related causes (ARD). In fully-adjusted models, abstainers had 30–50 % increased mortality risk compared to light-to-moderate drinkers. Adjusted hazard ratios (HR) in men drinking on average ≥60 g of ethanol/day (3 % of men) were 1.23 (95 % CI 0.95–1.59) for all-cause, 1.38 (0.95–2.02) for CVD, 1.64 (1.02–2.64) for CHD and 2.03 (1.28–3.23) for ARD mortality. Corresponding HRs in women drinking on average ≥20 g/day (2 % of women) were 1.92 (1.25–2.93), 1.74 (0.76–3.99), 1.39 (0.34–5.76) and 3.00 (1.26–7.10). Binge drinking increased ARD mortality in men only. Mortality was associated with high average alcohol intake but not binge drinking, except for ARD in men. The online version of this article (doi:10.1007/s10654-015-0092-8) contains supplementary material, which is available to authorized users.