Effects of caffeine on herpes simplex virus.
Effects of caffeine on herpes simplex virus.
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咖啡因对单纯疱疹病毒的影响。
作者：
Shiraki,K;Rapp,F
当咖啡因浓度大于1 mg/ml时，可抑制单纯疱疹病毒1型(HSV-1)斑块的形成，抑制HSV-1在复制周期不同阶段的生长，但不能灭活病毒的感染性。这些影响是相互独立的，并持续到病毒复制完成，如一步生长研究所确定的那样。在去除咖啡因后，一些复制步骤似乎恢复了。感染中心试验也显示咖啡因对HSV的传播有很强的抑制作用。咖啡因抑制蛋白质的合成，特别是三种病毒蛋白质的合成。
At concentrations greater than 1 mg/ml, caffeine inhibited plaque formation by herpes simplex virus type 1 (HSV-1), suppressed growth of HSV-1 at various steps of the replicative cycle, but did not inactivate virus infectivity. These effects were independent of each other and persisted through completion of virus replication, as determined by one-step growth studies. Some replication steps appeared to recover after removal of caffeine. Strong inhibition of the spread of HSV by caffeine also was demonstrated by infectious center assay. Caffeine suppressed protein synthesis, in particular that of three viral proteins.