Rab and Arf G proteins in endosomal trafficking and cell surface homeostasis.
Rab and Arf G proteins in endosomal trafficking and cell surface homeostasis.
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Rab 和 Arf G 蛋白在内体运输和细胞表面稳态中的作用。
DOI：
10.1080/21541248.2016.1212687
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Dutta,Dipannita
中科院分区：
文献类型：
--
作者：
Donaldson,JulieG;Johnson,DebraL;Dutta,Dipannita
内体膜系统中的膜融合、分裂、货物分选和细胞器成熟的动力学由Rab和Arf小G蛋白调节。定义每个Rab和Arf的调节因子、效应因子和作用位点将增强我们对内吞膜交通如何在分化的细胞类型中协调和发挥功能的理解。最近的工作还表明Rab35和Arf6可能作为2种形式的内吞作用的输入传感器来平衡膜运输以保持细胞表面稳态。
The dynamics of membrane fusion, fission, cargo sorting and organelle maturation in endosomal membrane systems is regulated by Rab and Arf small G proteins. Defining the regulators, effectors and sites of action for each Rab and Arf will enhance our understanding of how endocytic membrane traffic is orchestrated and functions in differentiated cell types. Recent work has also shown how Rab35 and Arf6 might serve as input sensors for 2 forms of endocytosis to balance membrane trafficking to preserve cell surface homeostasis.