Repair of alveolar cleft defect with mesenchymal stem cells and platelet derived growth factors: A preliminary report
Repair of alveolar cleft defect with mesenchymal stem cells and platelet derived growth factors: A preliminary report
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DOI：
10.1016/j.jcms.2011.02.003
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发表时间：
2012-01-01
影响因子：
3.1
通讯作者：
Atashi, Amir
中科院分区：
文献类型：
--
作者：
Behnia, Hossein;Khojasteh, Arash;Atashi, Amir
本研究旨在探讨重组血小板衍生生长因子对人骨髓间充质干细胞（hMSCs）在二次肺泡成形术中的促进作用。本研究选择了3例4个牙槽骨缺损的患者。间充质干细胞培养后髂骨穿刺。将MSC固定在双相支架上，并在手术室中与血小板衍生生长因子（PDGF）组合以制备支架、生长因子和细胞的三联体。将三联体放置在上颌前裂缺损处，并用侧向推进牙龈瓣闭合。采用锥形束CT扫描测量术后裂隙骨体积。术后3个月，骨缺损平均填充51.3%。我们的数据表明，使用重组血小板衍生生长因子与hMSCs可以增强细胞的再生能力。(C)2011年欧洲颅颌面外科协会。
The purpose of this study was to evaluate the enhancing effect of recombinant platelet derived growth factor on human mesenchymal stem cells (hMSCs) in secondary alveoloplasty. Three patients with 4 alveolar defects were selected for this study. Mesenchymal stem cells were cultured from a posterior iliac bone aspirate. MSCs were mounted on biphasic scaffolds and combined with platelet derived growth factor (PDGF) in the operating room to make a triad of the scaffold, growth factor, and cells. The triads were placed in anterior maxillary cleft defects and closed with lateral advancement gingival flaps. The postoperative cleft bone volume was measured with cone beam computed tomography scans. A mean of 51.3% fill of the bone defect was calculated 3 months post-operation. Our data suggests the use of recombinant platelet derived growth factor with hMSCs may enhance the regeneration capacity of the cells. (C) 2011 European Association for Cranio-Maxillo-Facial Surgery.