Consumption of black tea or coffee and risk of ovarian cancer
Consumption of black tea or coffee and risk of ovarian cancer
复制标题
DOI：
10.1111/j.1525-1438.2006.00773.x
复制
发表时间：
2007-01-01
影响因子：
4.8
通讯作者：
Moysich, K. B.
中科院分区：
文献类型：
--
作者：
Baker, J. A.;Boakye, K.;Moysich, K. B.
这项研究的目的是调查卵巢癌风险与经常饮用红茶、普通咖啡或不含咖啡因的咖啡之间的关系。采用基于医院的病例对照设计，参与者包括414名原发上皮性卵巢癌、输卵管癌或腹膜癌的女性和868名年龄和地区匹配的非肿瘤性疾病女性。所有参与者都完成了一份全面的流行病学问卷。饮用红茶与卵巢癌风险的线性下降有关（P为趋势0.03），每天饮用两杯或两杯以上的人患卵巢癌的风险下降了30%（调整后or为0.70,95% CI为0.51-0.97）。在每天饮用两杯或两杯以上无咖啡因咖啡的人群中，也出现了类似的下降（调整后or为0.71,95% CI为0.51-0.99；P为趋势值为0.002）。然而，没有发现经常喝咖啡和患卵巢癌的风险之间有任何联系。红茶和脱咖啡因咖啡中植物化学物质的化学保护作用可能很重要，尽管普通咖啡中植物化学物质的作用可能会被其高咖啡因含量带来的风险增加所抵消。
The goal of this study was to investigate the associations between ovarian cancer risk and usual consumption of black tea, regular coffee, or decaffeinated coffee. Using a hospital-based case-control design, participants included 414 women with primary epithelial ovarian, fallopian, or peritoneal cancer and 868 age- and region-matched women with nonneoplastic conditions. All participants completed a comprehensive epidemiologic questionnaire. Black tea consumption was associated with a linear decline in ovarian cancer risk (P for trend 0.03), with individuals consuming two or more cups daily experiencing a 30% decline in risk (adjusted OR 0.70, 95% CI 0.51-0.97). Similar declines were noted among individuals consuming two or more cups of decaffeinated coffee daily (adjusted OR 0.71, 95% CI 0.51-0.99; P for trend 0.002). However, no association was noted between any level of regular coffee consumption and risk of ovarian cancer. The chemoprotective effects of phytochemicals in black tea and decaffeinated coffee may be important, although the effects of phytochemicals in regular coffee may be counteracted by the elevated risk associated with its higher caffeine content.