Dynamics of cell orientation
Dynamics of cell orientation
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DOI：
10.1038/nphys680
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发表时间：
2007-09-01
期刊：
影响因子：
19.6
通讯作者：
Safran, Samuel A.
中科院分区：
文献类型：
--
作者：
De, Rumi;Zemel, Assaf;Safran, Samuel A.
许多生理过程依赖于生物细胞对由细胞收缩活动或外部应力产生的机械力的反应。使用一个简单的理论模型，其中包括由于细胞的机械敏感性和基质的弹性而产生的力，我们预测了在没有和存在施加应力的情况下细胞的动力学和方向。该模型预测了在细胞力和取向测量中观察到的许多特征，包括在没有施加应力的情况下细胞力随着时间的推移而增加，以及在存在准静态应力的情况下细胞力随之减少。我们还解释了令人费解的观察细胞平行排列的静态和准静态应力和几乎垂直排列的动态变化的应力。此外，我们预测了细胞取向对正弦变化的外加应力的响应，作为频率的函数。
Many physiological processes depend on the response of biological cells to mechanical forces generated by the contractile activity of the cell or by external stresses. Using a simple theoretical model that includes the forces due to both the mechanosensitivity of cells and the elasticity of the matrix, we predict the dynamics and orientation of cells in both the absence and presence of applied stresses. The model predicts many features observed in measurements of cellular forces and orientation including the increase with time of the cellular forces in the absence of applied stress and the consequent decrease of the force in the presence of quasi-static stresses. We also explain the puzzling observation of parallel alignment of cells for static and quasi-static stresses and of nearly perpendicular alignment for dynamically varying stresses. In addition, we predict the response of the cellular orientation to a sinusoidally varying applied stress as a function of frequency.