Psychopharmacologic Management of Eating Disorders.

Psychopharmacologic Management of Eating Disorders.
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DOI:
10.1007/s11920-022-01340-5
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发表时间:
2022-07
影响因子:
6.7
通讯作者:
Attia, Evelyn
Attia, Evelyn
中科院分区:
医学2区
文献类型:
--
作者:
Muratore, Alexandra F.;Attia, Evelyn

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识别可用作饮食失调治疗剂的药物是长期研究的焦点,并取得了不同程度的成功。本综述综合了三种饮食失调药物治疗的最新发现,包括神经性厌食症(AN)、神经性贪食症(BN)和暴食症(BED)。最近的研究表明,奥氮平对 AN 门诊患者的体重增加具有积极作用。 BN 和 BED 的精神药理学治疗近期进展较少,可能是由于之前的药物试验相对成功。奥氮平是第一种能够安全促进 AN 患者体重增加的药物。氟西汀经 FDA 批准用于 BN 治疗,赖右苯丙胺经 FDA 批准用于 BED 治疗。 BN 和 BED 通常对标签外处方的 SSRI 反应良好。迫切需要对其他饮食失调(例如回避限制性食物摄入障碍和其他特定的喂养和饮食失调)进行精神药理学治疗的研究。
Identifying medications that may be used as therapeutic agents for eating disorders is a longstanding focus of research, with varying degrees of success. The present review consolidates the most recent findings on pharmacological treatment of three eating disorders, including anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). Recent research suggests that olanzapine demonstrates positive effects on weight gain among outpatients with AN. There are fewer recent advances in psychopharmacological treatment for BN and BED, likely due to the relative success of prior medication trials. Olanzapine is the first medication to safely promote weight gain among individuals with AN. Fluoxetine is FDA-approved for BN treatment, and lisdexamfetamine is FDA-approved for BED treatment. BN and BED also generally respond well to SSRIs prescribed off-label. Research on psychopharmacological treatments for other eating disorders, such as avoidant-restrictive food intake disorder and other specified feeding and eating disorders, are sorely needed.
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