The effect of aging on the rat submandibular gland: An ultrastructural, cytochemical and biochemical study
The effect of aging on the rat submandibular gland: An ultrastructural, cytochemical and biochemical study
复制标题
衰老对大鼠颌下腺的影响：超微结构、细胞化学和生化研究
DOI：
10.1002/jmor.1051300306
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发表时间：
1970
影响因子：
1.5
通讯作者：
B. Bogart
中科院分区：
文献类型：
--
作者：
B. Bogart
采用超微结构、超微结构细胞化学和生化技术研究衰老对大鼠颌下腺的影响。在许多腺泡细胞中，核仁相关染色质和外周染色质出现与年龄相关的团块，粗内质网池的数量减少。许多衰老的腺泡细胞呈双核。整个腺体中色素颗粒的增加也与年龄相关。这些膜结合颗粒由一个脂滴和一个具有颗粒基质和色素滴的致密帽组成。酸性磷酸酶活性的铅捕获方法表明，活性与密集帽的颗粒基质有关。这些结果与比色法测定的酸性磷酸酶活性与年龄相关的增加有关。
The effect of aging on the rat submandibular gland was studied by using ultrastructural, ultrastructural cytochemical and biochemical techniques. There was an age‐related clumping of the nucleolar‐associated and peripheral chromatin in many of the acinar cells and a decrease in the number of cisternae of rough endoplasmic reticulum. Many aged acinar cells were binucleated. There was also an age‐related increase in pigment granules throughout the gland. These membrane bound granules consisted of a lipid droplet and an associated dense cap which had a granular matrix and pigment droplets. The lead capture method for acid phosphatase activity demonstrated that activity was associated with the granular matrix of the dense cap. These results were correlated with the age‐related increase in acid phosphatase activity as determined by colorimetric procedures.